Gastrodin Inhibits Store-Operated Ca2+ Entry and Alleviates Cardiac Hypertrophy [PDF]
Frontiers in Pharmacology, 2017 Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety issues.
Xiaoqiang Yao +18 more
doaj +3 more sources
Enhancing Gastrodin Production in Yarrowia lipolytica by Metabolic Engineering
ACS Synthetic BiologyGastrodin, 4-hydroxybenzyl alcohol-4-O-β-D-glucopyranoside, has been widely used in the treatment of neurogenic and cardiovascular diseases. Currently, gastrodin biosynthesis has been achieved in model microorganisms.
Yuanqing Wu +5 more
semanticscholar +3 more sources
Plants-derived neuroprotective agents: Cutting the cycle of cell death through multiple mechanisms [PDF]
, 2017 Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs).
Berida, Tomayo Ireti +2 more
core +13 more sources
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling. [PDF]
Acta Pharmacol SinDemyelination is a common feature of numerous neurological disorders including multiple sclerosis and leukodystrophies. Although myelin can be regenerated spontaneously following injury, this process is often inadequate, potentially resulting in ...
Shi XY +5 more
europepmc +2 more sources
Bioactive Materials, 2023 Wound healing is a highly orchestrated process involving a variety of cells, including immune cells. Developing immunomodulatory biomaterials for regenerative engineering applications, such as bone regeneration, is an appealing strategy. Herein, inspired
Limei Li +10 more
doaj +1 more source
Gastrodin promotes osteogenic differentiation by stimulating the Wnt/β-catenin signaling pathway
Molecular and Cellular ProbesBackground: Osteoporosis is a common disease that can lead to fracture as well as various skeletal symptoms and is a global health problem. Traditional Chinese medicine (TCM) may offer novel approaches for treating osteoporosis.
Wei Jiang +5 more
doaj +2 more sources
The effects of gastrodin injection on hypertension
Medicine, 2020 Abstract Background: Hypertension is a common chronic disease and poses a huge burden to health care systems. Recent studies have shown that gastrodin injection (GI) has a potential supplementary therapeutic effect on hypertension.
Lichao Qian +6 more
openalex +3 more sources
Gastrodin Induces Ferroptosis of Glioma Cells via Upregulation of Homeobox D10
Molecules, 2023 Gastrodin, the primary bioactive compound found in Gastrodia elata, has been shown to exhibit neuroprotective properties in a range of neurological disorders. However, the precise mechanisms through which gastrodin influences glioma cells remain unclear,
Wenpeng Cao +4 more
doaj +1 more source
Gastrodin attenuates angiotensin II-induced vascular contraction and MLCK/p-MLC2 pathway activation
Pharmaceutical Biology, 2023 Context Gastrodin has been used as antihypertension therapy in China; however, the mechanisms underlying the effects of gastrodin have yet to be fully elucidated.Objective To explore the therapeutic efficiency of gastrodin as an antihypertensive and ...
Zhi Guo +8 more
doaj +1 more source
Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial. [PDF]
Crit CareDelirium and postoperative cognitive dysfunction (POCD) are common complications post-cardiac surgery, yet no specific medical intervention is currently recommended for prevention.
Bai YX +9 more
europepmc +2 more sources