Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism
Frontiers in Pharmacology, 2021 As a severe metabolic disease, type 2 diabetes mellitus (T2DM) has become a serious threat to human health in recent years. Gastrodin, as a primary chemical constituent in Gastrodia elata Blume, has antidiabetic effects.
Yu Bai +6 more
doaj +1 more source
Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration
Pharmaceuticals, 2022 Gastrodin, a traditional Chinese medicine ingredient, is widely used to treat vascular and neurological diseases. However, recently, an increasing number of studies have shown that gastrodin has anti-osteoporosis effects, and its mechanisms of action ...
Yi Li, Fenglan Li
doaj +1 more source
Nutrition & Metabolism, 2023 Background Gastrodin is an effective polyphenol extracted from Chinese natural herbal Gastrodiae elata Blume, which exhibits antioxidant and anti-inflammatory effects.
Xiaofei Xue +6 more
doaj +1 more source
Brain Sciences, 2023 Gastrodin is the active ingredient in Gastrodia elata. Our previous studies demonstrated that gastrodin ameliorated cerebral ischemia–reperfusion and hypoperfusion injury and improved cognitive deficit in Alzheimer’s disease.
Bo Liu +4 more
doaj +1 more source
Mechanisms Underlying Gastrodin Alleviating Vincristine-Induced Peripheral Neuropathic Pain [PDF]
Frontiers in Pharmacology, 2021 Gastrodin (GAS) is the main bioactive ingredient of Gastrodia, a famous Chinese herbal medicine widely used as an analgesic, but the underlying analgesic mechanism is still unclear. In this study, we first observed the effects of GAS on the vincristine-induced peripheral neuropathic pain by alleviating the mechanical and thermal hyperalgesia.
Xiangyu Wang +15 more
openaire +3 more sources
Pharmacological Study of Phenolic Components in Parkinson's Disease [PDF]
, 2022 In this study, cell experiments were conducted to investigate the effects of extracts on cell viability and apoptosis of Parkinson model in vitro, as well as the expression of cysteine protease-3 (Caspase-3) and B lymphocytoma-2-associated X protein (BAX)
Dong, Xin +4 more
core +2 more sources
Gastrodia elata powder capsule enhances anti-epileptic effect of carbamazepine by decreasing P-gp expression [PDF]
, 2021 Purpose: To investigate the influence of Gastrodia elata powder capsule (GC) or gastrodin (GTD) on the anti-epileptic effect of carbamazepine (CBZ) on penicillin (PG)-induced epilepsy in rats. Methods: A total 116 rats were used in this study.
Dang, Xiangji +4 more
core +2 more sources
Gastrodin Injection Relieves Hypoxic-Ischemic Brain Injury in Newborn Rats by Regulating the P62/Nrf2/HO-1 Pathway. [PDF]
Mol NeurobiolHypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal mortality and disability, yet effective treatments remain limited. Gastrodia elata is a Chinese medicinal herb that has both medicinal and edible properties. Previous studies have shown
Wu S +7 more
europepmc +2 more sources
A review: Mechanism and prospect of gastrodin in prevention and treatment of T2DM and COVID-19
Heliyon, 2023 Gastrodin is an extract from the dried tuber of the Chinese herb Gastrodia elata (Tian ma), with anti-inflammatory, antioxidant, and antiviral properties.
Yi Li, Yuanyuan Ji, Fenglan Li
doaj +1 more source
Pharmacological Effects of Active Compounds on Neurodegenerative Disease with Gastrodia and Uncaria Decoction, a Commonly Used Poststroke Decoction [PDF]
, 2013 published_or_final_versio
Chik, SCC +4 more
core +1 more source