Origin discrimination and quality evaluation of Gastrodiae rhizoma (Orchidaceae) by high-performance liquid chromatographic fingerprint [PDF]
, 2016 Purpose: To develop a high-performance liquid chromatography (HPLC) fingerprint method for the quality control and origin discrimination of Gastrodiae rhizoma.Methods: Twelve batches of G.
Feng, Guang-fu +5 more
core +2 more sources
Exploring Gastrodin Against Aging-Related Genes in Alzheimer's Disease by Integrated Bioinformatics Analysis and Machine Learning. [PDF]
Int J Mol SciGastrodin is the main active ingredient of Gastrodia elata Blume, known for its prominent neuroprotective effects, especially in Alzheimer’s disease. Meanwhile, aging is a critical risk factor in age-related diseases, including AD.
Zhou L +7 more
europepmc +2 more sources
Gastrodin Alleviates Tau Pathology by Targeting the Alzheimer's Risk Gene FERMT2, Reversing the Reduction in Brain Viscoelasticity. [PDF]
CNS Neurosci TherThe pathogenesis of Alzheimer's disease (AD) remains incompletely elucidated, and there is a notable deficiency in effective and safe therapeutic interventions.
Wang L +7 more
europepmc +2 more sources
Natural antioxidants may prevent posttraumatic epilepsy: a proposal based on experimental animal studies. [PDF]
, 2004 Head injury or hemorrhagic cortical infarction results in extravasation of blood and breakdown of red blood cells and hemoglobin. Iron liberated from hemoglobin, and hemoglobin itself, are associated with the generation of reactive oxygen species (ROS ...
Mori, Akitane +3 more
core +1 more source
Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model
BMC Neuroscience, 2019 Background Recently, the use of traditional Chinese medicine (TCM) has become more generally accepted, including by the Food and Drug Administration. To expand the use of TCM worldwide, it is important to study the molecular mechanisms by which TCM and ...
Jinyuan Yan +4 more
doaj +1 more source
Role of Intestinal Microbiota in Metabolism of Gastrodin In Vitro and In Vivo
Metabolites, 2019 Alteration in the number and composition of intestinal microbiota affects the metabolism of several xenobiotics. Gastrodin, isolated from Gastrodia elata, is prone to be hydrolyzed by intestinal microbiota.
Mahesh Raj Nepal +7 more
doaj +1 more source
[Gastrodin inhibits ferroptosis to alleviate hypoxic-ischemic brain damage in neonatal mice by activating GPX4/SLC7A11/FTH1 signaling]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoGuo T +8 more
europepmc +2 more sources
Identification and Characterization of Key Chemical Constituents in Processed Gastrodia elata Using UHPLC-MS/MS and Chemometric Methods [PDF]
, 2019 © The Author(s) 2019. Background. Obesity is a major medical issue nationally, with rates continually increasing. In obese patients, minimal data exist for appropriate dosing of acyclovir to decrease the rates of nephrotoxicity. The purpose of this study
Avula, Bharathi +9 more
core +2 more sources
FoodsInflammatory bowel diseases (IBDs) are commonly associated with dysfunctional intestinal barriers and disturbed gut microbiota. Gastrodin, a major bioactive ingredient of Gastrodia elata Blume, has been shown to exhibit anti-oxidation and anti ...
Jiahui Li +6 more
doaj +1 more source
Gastrodin alleviates bone damage by modulating protein expression and tissue redox state
FEBS Open Bio, 2020 Fluorosis is a common disease characterized by disruptions in bone metabolism and enamel development. The production of reactive oxygen species is thought to play an important role in fluorosis. Gastrodin (4‐hydroxybenzylalcohol4‐O‐beta‐D‐glucopyranoside)
Bowen Zheng +5 more
doaj +1 more source