Gastrodin ameliorates Parkinson’s disease by downregulating connexin 43
Molecular Medicine Reports, 2013 Gastrodin, the predominant constituent of a Chinese herbal medicine, has been utilized in the prevention of Parkinson's disease (PD); however, its mechanism of action remains unknown. Astrocytes are involved in PD and are proposed to be coupled with gap junction connexin 43 (Cx43).
Yu, Wang, Zhe, Wu, Xu, Liu, Qunying, Fu
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Gastrodia Elata Bl Attenuates Cocaine-Induced Conditioned Place Preference and Convulsion, but not Behavioral Sensitization in Mice: Importance of GABAA Receptors [PDF]
, 2011 It has been suggested that GABAergic neurotransmission can modulate cocaine dependence and seizure activity. Since Gastrodia elata Bl (GE), an oriental herb agent, has been shown to enhance GABAergic transmission, we examined whether GE affects cocaine ...
Ali, S.F +10 more
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Effects of Gastrodin on Analgesia and Inhibition of Ferroptosis [PDF]
, 2021 Abstract Background: Gastrodin possesses low toxicity and a broad range of pharmacological activities and exhibits beneficial effects in neurological diseases. This study investigated the effects of gastrodin (GAS) on analgesic, anti-inflammatory, anxiolytic and inhibition of ferroptosis.
JinYue Wang +3 more
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Gastrodin, a Promising Natural Small Molecule for the Treatment of Central Nervous System Disorders, and Its Recent Progress in Synthesis, Pharmacology and Pharmacokinetics. [PDF]
Int J Mol SciGastrodia elata Blume is a traditional medicinal and food homology substance that has been used for thousands of years, is mainly distributed in China and other Asian countries, and has always been distinguished as a superior class of herbs. Gastrodin is
Dai Y, Ban W, Yang Z.
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Gastrodin ameliorates synaptic impairment, mitochondrial dysfunction and oxidative stress in N2a/APP cells [PDF]
Alzheimer's disease is characterized by abnormal β-amyloid and tau accumulation, mitochondrial dysfunction, oxidative stress, and synaptic dysfunction.
Chen, Zhuyi +10 more
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Molecules, 2022 Gastrodiae rhizoma (GR) formula granules and preparations have been used as a popular traditional Chinese medicine for clinical treatment since they have good pharmacological activity to treat nervous system diseases.
Shuting Xie +8 more
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Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats [PDF]
, 2015 Aquest article conté una errata annexadaOtotoxicity is known to cause permanent loss of vestibule function through degeneration of sensory hair cells (HCs). However, functional recovery has been reported during washout after chronic ototoxicity, although
Boadas i Vaello, Pere +3 more
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Ibrain, EarlyView.Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
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Role of p38 MAPK inhibitor in conditioned fear [PDF]
, 2015 p38 mitogen activated protein kinase (p38) is a kinase that has been implicated in cellular plasticity, stress, and psychiatric disorders and recently in the process of DNA repair.
Bauman, Brittany Nicole +1 more
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Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Focused ultrasound is rapidly emerging as a novel technology for the development of symptomatic therapies and supporting disease‐modifying treatments for Parkinson's disease (PD). At the forefront of this development is thermoablation using high‐intensity focused ultrasound, an incisionless treatment that has been extensively tested in ...
Rikke Hahn Kofoed +7 more
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