Results 51 to 60 of about 8,469 (217)

In vitro and in vivo evaluation of thapsigargin as an antiviral agent against transmissible gastroenteritis virus

Veterinary Research
Swine enteric coronaviruses (SeCoVs) pose a significant threat to the global pig industry, but no effective drugs are available for treatment. Previous research has demonstrated that thapsigargin (TG), an ER stress inducer, has broad-spectrum antiviral ...
Yang Li, Yuanyuan Liu, Yunhang Zhang, Chen Tan, Yifei Cai, Yue Zhang, Jianing Chen, Yuguang Fu, Guangliang Liu   +8 more
semanticscholar   +1 more source

Identification of Outer Membrane Vesicles as a New Vehicle Mediating Antibiotic Resistance Gene Transfer in Campylobacter

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
ABSTRACT The emergence and worldwide dissemination of antibiotic resistance genes (ARGs) compromise antibiotic therapy and are a major public health crisis. Horizontal gene transfer (HGT) plays a major role in the spread of ARGs among bacterial pathogens.
Mengyu Zhao, Min He, Xiaolong Lin, Ke Wu, Fang Yang, Xinggui Chen, Haozheng Li, Hongning Wang, Yizhi Tang   +8 more
wiley   +1 more source

The essential role of mitochondrial dynamics in antiviral immunity. [PDF]

, 2018
Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation.
Ahn, Dae-Gyun, Kim, Seong-Jun, Siddiqui, Aleem, Syed, Gulam H   +3 more
core   +2 more sources

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Elevated dietary zinc oxide levels do not have a substantial effect on porcine reproductive and respiratory syndrome virus (PPRSV) vaccination and infection [PDF]

, 2014
Background Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important infectious agents for the swine industry worldwide.
Blohm, Ulrike, Burwinkel, Michael, Chai, Weidong, Janczyk, Pawel, Osterrieder, Nikolaus, Twardziok, Sven, Wang, Zhenya   +6 more
core   +3 more sources

Integrated Metabolomic and transcriptomic analyses reveal deoxycholic acid promotes transmissible gastroenteritis virus infection by inhibiting phosphorylation of NF-κB and STAT3

BMC Genomics
Background Acute diarrhea, dehydration and death in piglets are all symptoms of transmissible gastroenteritis virus (TGEV), which results in significant financial losses in the pig industry. It is important to understand the pathogenesis and identify new
Yajing Zhou, Chao Xu, Shan Gu, Yeyi Xiao, Shenglong Wu, Haifei Wang, Wen-hua Bao   +6 more
semanticscholar   +1 more source

Myricetin inhibits transmissible gastroenteritis virus replication by targeting papain-like protease deubiquitinating enzyme activity

Frontiers in Microbiology
Myricetin, a natural flavonoid found in various foods, was investigated for its antiviral effect against transmissible gastroenteritis virus (TGEV). This α-coronavirus causes significant economic losses in the global swine industry.
Jiahao Fan, Pengyuan Xi, Huimao Liu, Xu Song, Xinghong Zhao, Xun Zhou, Y. Zou, Yuping Fu, Lixia Li, Renyong Jia, Z. Yin   +10 more
semanticscholar   +1 more source

Advice on the suitability of VR 2827‐3 as a disinfectant for slaughtering equipment in the meat processing industry

Food Risk Assess Europe, Volume 3, Issue 4, October 2025.
Cross‐contamination between carcasses can occur during slaughter if tools are contaminated with pathogenic microorganisms. To prevent this, the EU Hygiene Regulation requires disinfection of these tools with water of at least 82°C or an equivalent alternative. A Dutch slaughterhouse proposed using disinfectant VR 2827‐3 instead of hot water.
L.P.B. Verhoef, D.T.H.M. Sijm
wiley   +1 more source

Antigenic and biological diversity among transmissible gastroenteritis virus isolates of swine

Veterinary Microbiology, 1993
Twenty-four field isolates of transmissible gastroenteritis virus (TGEV) were isolated and examined for antigenic and biological characteristics. Most TGEV isolates produced a typical cytopathic effect (CPE) in swine testis (ST) cell culture, which included a ballooning or lifting away of the infected cells from the cell monolayer with heavy ...
Vaughn, Eric M., Paul, Prem S.
openaire   +2 more sources

Porcine ex-vivo intestinal mucus has age-dependent blocking activity against transmissible gastroenteritis virus

Veterinary Research
Transmissible gastroenteritis virus (TGEV) causes high mortality in young piglets (
Waqar Saleem, Nathan Carpentier, C. Hinnekens, Dayoung Oh, S. van Vlierberghe, K. Braeckmans, Hans J. Nauwynck   +6 more
semanticscholar   +1 more source