Results 41 to 50 of about 87,420 (220)

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Creating more than a directory: improving handover of information by renovating the induction app for University Hospital Wishaw

BMJ Open Quality, 2020
Starting in a new hospital can be an overwhelming experience for any grade of doctor. There is a vast amount of information that needs to be learnt immediately to function in the new environment. There is an annual changeover of doctors between hospitals
Manish Patel, Jennifer Cathcart, Kathleen Clare   +2 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

25-Hydroxycholesterol restricts human norovirus replication in human intestinal enteroids

Journal of Virology
Norovirus is the leading cause of acute gastroenteritis worldwide. Since the development of human intestinal enteroid (HIE) cell culture systems, significant advancements have been made in exploring and evaluating therapeutic strategies to combat human ...
Verónica Costantini, Wadzanai P. Mboko, Helen Wall, Kimberly Huynh, Anna M. Montmayeur, Geun Woo Park, Ruijie Xu, Jan Vinjé, Preeti Chhabra   +8 more
doaj   +1 more source

Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report

Journal of Medical Case Reports, 2019
Background Until today, classic human astroviruses have not been associated with central nervous system infections in immunocompetent patients. Case presentation A 16-month-old Caucasian girl presented with repetitive generalized seizures with a 4-day ...
Georgia Koukou, Sandra Niendorf, Britt Hornei, Jan-U Schlump, Andreas C. Jenke, Sonja Jacobsen   +5 more
doaj   +1 more source

Manajemen Gastroenteritis pada Anak: Literature Review

Jurnal Keperawatan Klinis dan Komunitas (Clinical and Community Nursing Journal), 2020
Background: Gastroenteritis is a common infectious disease in children, especially children under 5 years of age. Gastroenteritis that is not handled properly can cause hypovolemic shock thereby increasing mortality in children.
Ami Novianti Subagya, Ririn Mutia Zukra, Laila Nidaul Hasanah   +2 more
doaj   +1 more source

Sistem Pendukung Keputusan Diagnosa Gastroenteritis Menggunakan Metode Analytical Hierarchy Process

JOINS (Journal of Information System), 2021
Penyakit diare masih merupakan masalah kesehatan masyarakat di negara berkembang seperti di Indonesia, berdasarkan survei hasil data dari puskesmas Kembangan selama 2 bulan terakhir mengalami peningkatan.
Fahmy Umarsyah, Naufal Bagaskara, Yuwan Jumaryadi   +2 more
doaj   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Enteric Viruses and Inflammatory Bowel Disease

Viruses, 2021
Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a multifactorial disease in which dietary, genetic, immunological, and microbial factors are at play.
Georges Tarris, Alexis de Rougemont, Maëva Charkaoui, Christophe Michiels, Laurent Martin, Gaël Belliot   +5 more
doaj   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source