Results 211 to 220 of about 522,889 (310)

Comprehensive Assessment of Direct and Passive Smoking Across the Pancreatitis Spectrum. [PDF]

open access: yesPancreas
Han S   +18 more
europepmc   +1 more source

Differences in Biologic Clinical Trials for Chronic Rhinosinusitis With Nasal Polyps—Are We Comparing Apples With Oranges?

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
Key Points In recent years, several biologics targeting Type 2 inflammation have been developed for treating chronic rhinosinusitis with nasal polyps (CRSwNP). These have been studied in registrational randomized controlled trials (RCTs), which vary in their patient populations, trial design, endpoints, geography, timing, or data‐handling processes ...
Marjolein Cornet   +10 more
wiley   +1 more source

Emotional Burden of Olfactory Dysfunction: A Psychological Cluster Analysis from a Tertiary Smell and Taste Clinic

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
Key Points The emotional burden of olfactory dysfunction bears distinct psychological profiles. Objective olfactory dysfunction findings do not reliably reflect patients' emotional burden. Olfactory‐related quality of life assessment may identify patient risk of emotional distress.
Tom Fischer   +8 more
wiley   +1 more source

Induction and Prolonged Induction With Mirikizumab in Ulcerative Colitis-A Prospective, Real-World Study From the Sicilian Network for Inflammatory Bowel Disease (SN-IBD). [PDF]

open access: yesUnited European Gastroenterol J
Costantino G   +24 more
europepmc   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu   +9 more
wiley   +1 more source

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel   +9 more
wiley   +1 more source

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