Results 51 to 60 of about 4,958,749 (292)

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Prevalence and Risk Factors of Gastroesophageal Reflux Disease Among Medical and Dental Students of Rawalpindi/Islamabad

Pakistan Armed Forces Medical Journal
Objectives: To determine the prevalence of gastroesophageal reflux disease among medical and dental students of Rawalpindi Islamabad Pakistan and to find the associated risk factors. Study Design: Analytical cross-sectional study.
Asima Shahzad, Syed Fawad Mashhadi, Mehreen Shahid, Sumaira Khalid, Ata Ur Rehman, Ashan Mukhtar, Ishraq Ahmed   +6 more
doaj   +1 more source

Artificial Intelligence for Benign Esophageal Stricture Dilation: An Evidence‐Transferability Framework and Safety‐First Roadmap

AI &Innovation, EarlyView.
ABSTRACT Background Endoscopic dilation is first‐line therapy for symptomatic benign esophageal strictures but remains operator‐dependent. Artificial intelligence (AI) could support assessment, risk stratification, and documentation; however, evidence from adjacent tasks is often mistaken for procedure‐specific validation.
Ahmed A. Salman, Mohamed A. Salman
wiley   +1 more source

Diagnosis of extraesophageal manifestations of GERD: an interdisciplinary approach

Лечащий Врач
Background. Current concepts define gastroesophageal reflux disease as a chronic, recurrent condition, characterised by impaired upper gastrointestinal motility, gastroesophageal junction dysfunction, and pathological gastroesophageal reflux.
M. A. Livzan, O. V. Gaus, K. I. Nesterova, N. P. Algazina   +3 more
doaj   +1 more source

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert, Gudny Anna Arnadottir, Laura Bedinger, Nicola Brunetti‐Pierri, Jennifer Cech, Xin Chen, Yanmin Chen, Erika Chick, Sarah Dyack, Madeleine Franchi, Tanja Frey, David Genevieve, Ian Glass, Jorge Granadillo, Kelly A. Keener, Sara B. MacKay, Paige McDunnah, Vinod K. Misra, Kristin G. Monaghan, Sureni V. Mullegama, Cristina Peduto, Leia Peterman‐Prather, Anita Rauch, Cherith Somerville, Kari Stefansson, Katharina Steindl, Patrick Sulem, Telma Sulem, Pamela Trapane, Roberta Zeuli, Samuel Zinner, Kosuke Izumi   +31 more
wiley   +1 more source

Induced Opening of the Gastroesophageal Junction Occurs at a Lower Gastric Pressure in Gerd Patients and in Hiatal Hernia Subjects than in Normal Control Subjects

Gastroenterology Research and Practice, 2010
Purpose. To determine intragastric pressure threshold for inducing gastroesophageal junction (GEJ) opening in normal control subjects with and without hiatal hernia, and in patients with gastroesophageal reflux disease. Methods.
Anil Vegesna, Ramashesai Besetty, Amit Kalra, Umar Farooq, Annapurna Korimilli, Keng yu Chuang, Robert Fisher, Henry Parkman, Larry Miller   +8 more
doaj   +1 more source

Systematic Cardiac Phenotyping of Patients With Copy Number Variants in the 15q11.2 Breakpoint 1 to Breakpoint 2 Region: A Retrospective Cohort Study From Nine Pediatric Cardiac Centers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Microdeletions impacting 15q11.2 breakpoint (BP) 1 to BP2, adjacent to the Prader–Willi critical region, have previously described neuropsychiatric associations, with potential low penetrance presentations of congenital heart disease (CHD) also identified.
Morgan B. Wright, Maria B. Padua, Lindsey R. Helvaty, Kim L. McBride, Gabrielle Geddes, Vidu Garg, Seema R. Lalani, Stephanie Burns Wechsler, Jennelle C. Hodge, Benjamin J. Landis, Stephanie M. Ware   +10 more
wiley   +1 more source

Diabetes mellitus and comorbid gastroesophageal reflux disease:risk factors and dynamics

Сеченовский вестник, 2017
We analyzed the dynamics of comorbid gastroesophageal reflux disease and type 2 diabetes mellitus. The sudy involved 216 patients with diagnosed type 2 diabetes mellitus combined with gastroesophageal reflux disease.
M. A. Kunitsyna, E. I. Kashkina, T. M. Semikina, E. V. Zhukova   +3 more
doaj  

SURGICAL TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE IN CHILDREN WITH NEUROLOGICAL DISORDERS ACCOMPANIED BY IMPAIRED SWALLOWING

Педиатрическая фармакология, 2013
The article is dedicated to the issue of gastroesophageal reflux treatment in infants with neurological disorders, which remains insufficiently studied and unsettled.
M. G. Dzhilavyan, L. M. Kuzenkova, T. V. Podkletnova, A. A. Shavrov (junior)   +3 more
doaj   +1 more source