Results 151 to 160 of about 3,449 (213)

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

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Ingestible Contrast Agents for Gastrointestinal Imaging

ChemBioChem, 2019
AbstractGastrointestinal (GI) ailments cover a wide variety of diseases involving the esophagus, stomach, small intestine, large intestine, and rectum. They bring about many inconveniences in daily life in chronic diseases and can even be life threatening in acute cases.
Yumiao Zhang, Jonathan F. Lovell, Xingyue Yang   +2 more
exaly   +3 more sources

ANTISECRETORY AGENTS IN GASTROINTESTINAL OBSTRUCTION

Clinics in Geriatric Medicine, 2000
Gastrointestinal obstruction is associated with nausea, vomiting, and abdominal pain. Antisecretory agents can relieve these symptoms, even in the absence of surgical or mechanical intervention. These medical management approaches are outlined, and recommendations are made.
J C, Muir, C F, von Gunten
openaire   +2 more sources

Gastrointestinal Iodinated Contrast Agents

2021
Oral contrast agents are categorized as “positive” (radiodense) or “neutral” (water attenuation). Positive agents are administered to opacify the bowel lumen and thus to improve the differentiation of bowel from non-bowel structures. The two main classes of positive oral contrast agents are barium sulfate suspensions and water-soluble iodinated ...
Suzan Saylisoy, Sukru Mehmet Erturk
openaire   +1 more source

Novel chemotherapeutic agents for gastrointestinal cancers

Current Opinion in Oncology, 1999
Although 5-fluorouracil has been the most commonly prescribed chemotherapy agent in the treatment of patients with gastrointestinal malignancies, new agents discussed herein provide options for the treatment of patients with colorectal, gastric, and pancreas cancer.
M E, Royce, R, Pazdur
openaire   +2 more sources

Polymeric gastrointestinal MR contrast agents

Journal of Magnetic Resonance Imaging, 1991
AbstractCombining either paramagnetic (gadolinium chelatea) or superparamagnetic (ferrite) contrast agents with polymers such as polyethylene glycol or cellulose, or with simple sugars such as dextrose, results in mixtures that exhibit improved T1 and/or T2 relaxivity compared with that of the contrast agent alone.
C, Tilcock, E C, Unger, Q F, Ahkong, T, Fritz, S H, Koenig, R D, Brown   +5 more
openaire   +2 more sources

Psychotropic agents in functional gastrointestinal disorders

Current Opinion in Pharmacology, 2008
Functional gastrointestinal disorders (FGIDs) are common conditions diagnosed by established symptom-based criteria. Dysregulation of the brain-gut axis is emerging as the primary pathophysiologic mechanism for FGIDs; this opens avenues for newer treatment modalities.
Madhusudan, Grover, Douglas A, Drossman
openaire   +2 more sources

Erythromycin as a gastrointestinal prokinetic agent

Intensive and Critical Care Nursing, 2001
Erythromycin is a potent stimulator of gastrointestinal (GI) motility and can be a useful agent to treat GI stasis in patients who are critically ill. However, it is not licensed for this indication and has serious drug interactions which may limit its utility.
openaire   +2 more sources

Gastrointestinal contrast agents: A diamagnetic approach

Magnetic Resonance in Medicine, 1988
AbstractThe clay minerals kaolin and bentonite are demonstrated as gastrointestinal contrast agents for MRI. Weak field dependence of the relaxation efficiency assures effectiveness of these agents at all field strengths in clinical use. These agents eliminate signals from their immediate environment and are not toxic. © 1988 Academic Press, Inc.
J J, Listinsky, R G, Bryant
openaire   +2 more sources

Gastrointestinal Toxicity of Chemotherapeutic Agents

Seminars in Oncology, 2006
Chemotherapy-induced toxicities commonly occur in sites within the gastrointestinal (GI) tract and account for dose-limiting effects. These toxicities are major contributing factors to dose reduction, delays, and cessation of cancer treatment. Through intensive therapies including surgery, combination chemotherapy, hormonal therapy, and targeted ...
openaire   +3 more sources