Results 251 to 260 of about 4,823,404 (316)

A Multidisciplinary, Digitally-Integrated Life-Cycle Management Model for Early Gastrointestinal Cancer: Enhancing Care Coordination and Continuity. [PDF]

J Multidiscip Healthc
Yuan R, Gong H, Tang C, Hu B, Gao J, Wu H, Yang W.   +6 more
europepmc   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Immunonutrition Decreases Postoperative Complications in Gastrointestinal Cancer-A Systematic Review and Meta-analysis of Randomized Controlled Trials. [PDF]

Adv Nutr
Budai BC, Panait R, Laczkó B, Cai G, Váncsa S, Veres DS, Fazekas KK, Szalai EÁ, Hagymási K, Erőss B, Földvári-Nagy L, Hegyi P, Bunduc S.   +12 more
europepmc   +1 more source

NSUN3‐Associated m5C Modification of tRF5‐GlyTCC Suppresses Colorectal Cancer Progression via RPL23‐Linked Nucleolar Stress and p53‐Associated Autophagy and Enhances 5‐FU Sensitivity

Advanced Science, EarlyView.
This study identifies that NSUN3‐mediated m5C modification stabilizes tRF5‐GlyTCC, linking ribosomal homeostasis, nucleolar stress responses, and p53 signaling changes. This regulatory axis suppresses colorectal cancer and enhances chemotherapy response to 5‐FU, positioning tRF5‐GlyTCC as a potential therapeutic target for improving drug sensitivity in
Xinhui Lv, Can Tang, Feiyang Song, Yu Wu, Yafang Chen, Sicong Liu, Ziwen Yuan, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Gut microbiota-derived metabolites in gastrointestinal cancer: immunomodulatory mechanisms via the tryptophan-AhR axis and translational perspectives. [PDF]

Front Immunol
Xing X, Ying H, Wang DX, Han S.
europepmc   +1 more source

Noninvasive Detection and Subtyping of Esophageal Cancer by Circulating Cell‐Free mtDNA Fragmentomics: A Multi‐Center Validation Study

Advanced Science, EarlyView.
Circulating cell‐free mitochondrial DNA provides a robust, noninvasive platform for early detection and histological subtyping of esophageal cancer. This large multi‐center study validates consistently high accuracy across ethnically and geographically diverse cohorts, demonstrating strong potential to transform clinical management. ABSTRACT Esophageal
Yue Liu, Wenying Yang, Yu Li, Siyuan Wang, Xiang Li, Fan Peng, Miao Dang, Huanqin Zhang, Huanmin Jiao, Yuqing Yang, Zhaoquan Su, Xiumin Ma, Zhiyun Gong, Renquan Lu, Jinliang Xing, Yang Liu   +15 more
wiley   +1 more source

Prevalence and Prognostic Role of Nutrition Impact Symptoms in Patients With Gastrointestinal Cancer: A Multicenter Cohort Study. [PDF]

In Vivo
Zhang HY, Yang M, Ge YZ, Zhang QI, Zhang XI, Tang M, Wang ZW, Song MM, Ruan GT, Zhang XW, Liu T, Xie HL, Liu CA, Shi JY, Zhang KP, Liu XY, Lin SQ, Chen Y, Zheng X, Shi HP, Qu XJ.   +20 more
europepmc   +1 more source

An Explainable Multimodal Deep‐Learning Model Using Histopathological Image and Clinical Information for Prognosis Prediction in Colorectal Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study develops a multimodal deep‐learning model that integrates clinical variables and histopathological images to predict survival outcomes in colorectal cancer. The multimodal model effectively stratifies patients into low‐ and high‐risk groups, demonstrating superior accuracy and generalizability across multiple independent cohorts.
Zhihan Jiang, Xiangchao Shi, Chenghan Su, Yao Ma, Rui Li, Menglei Chen, Jianxin Cui, Nicholas Hawkins, Robyn Ward, Xiangzhi Bai, Jitendra Jonnagaddala, Wei Fu, Xin Zhou   +12 more
wiley   +1 more source

Moxibustion for gastrointestinal cancer-related fatigue: study protocol for a randomized clinical trial. [PDF]

Front Psychiatry
Liu H, Fan Q, Yao W, Liu L, Hu J, Yin P, Chen Y.   +6 more
europepmc   +1 more source

Emerging role of protein arginine methyltransferase 5 in gastrointestinal cancer (Review). [PDF]

Oncol Lett
Zhang R, Lu Y, Fang X, Zhang F, Wu W, Song J, Liang Z.   +6 more
europepmc   +1 more source