Results 101 to 110 of about 3,166,315 (255)

External validity of cardiovascular risk assessment tools in individuals with MASLD (NAFLD): a cohort study

Scientific Reports
The present study was conducted to evaluate the external validity of various cardiovascular disease (CVD) risk assessment tools in predicting CVD events among individuals with metabolic dysfunction–associated steatotic liver disease (MASLD).
Nima Motamed, Mahmoodreza Khoonsari, Mohammad Hadi Karbalaie Niya, Mahshid Panahi, Hossein Ajdarkosh, Mansooreh Maadi, Maral Ahmadi, Dhayaneethie Perumal, Hossein Ashrafi, Fahimeh Safarnezhad Tameshkel, Bahareh Amirkalali, Maziar Moradi-Lakeh, Farhad Zamani   +12 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Diagnostic Value of Faecal M2PK and FIT in Colorectal Cancer Screening [PDF]

Caspian Journal of Health Research
Background: The mortality rate of colorectal cancer could be declined by immediate diagnosis. Objectives: We surveyed the potentials of two diagnostic methods, M2 pyruvate kinase (M2PK) and fecal immunochemical tests (FIT), in comparison to colonoscopy ...
Farahnaz Joukar, Mohammad Saghafi, Sara Yeganeh, Soheil Hassanipour, Fariborz Mansour-Ghanaei   +4 more
doaj  

Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich, Alexis Ogdie, Alisa Stephens Shields, Peter A. Merkel, Shervin Assassi, Elana J. Bernstein, Andreea Bujor, Flavia V. Castelino, Lorinda Chung, Luke B. Evnin, Tracy M. Frech, Jessica K. Gordon, Melissa Griffith, Faye N. Hant, Monica L. Harding, Laura K. Hummers, Dinesh Khanna, Kimberly S. Lakin, Dorota J. Lebiedz‐Odrobina, Yiming Luo, Ashima Makol, Maureen D. Mayes, Zsuzsanna H. McMahan, Jerry Molitor, Duncan F. Moore, Julie Paik, Carrie Richardson, Brian Skaug, Ami A. Shah, Ankoor Shah, Virginia Steen, John M. VanBuren, Elizabeth R. Volkmann, Carleigh Zahn, Nora Sandorfi, for the CONQUER Investigators   +35 more
wiley   +1 more source

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source

Obesity and Upper Gastrointestinal Diseases

Obesity increases gastroesophageal reflux disease through several factors. As a result, Barrett's esophagus, esophageal adenocarcinoma, and gastroesophageal junctional gastric cancer are increasing.
Younghee Choe
core   +1 more source

Prevalence of HSV-1, HSV-2, EBV, and HHV-8 Co-Infections Among HPV-Positive Women: A Cross-Sectional Study from Iran

International Journal of General Medicine
Fahimeh Safarnezhad Tameshkel,1 Ali Salimi Jeda,2 Mozhan Sadat Ghaemi,3 Angila Ataei-Pirkooh,4 Parastoo Motamedaria,4 Gholamreza Hemmasi,5 Mahtab Motevasselian,6,7 Zahra Panahi,1 Mohammad Hadi Karbalaie Niya1,4 1Gastrointestinal and Liver Diseases ...
Safarnezhad Tameshkel F, Salimi Jeda A, Sadat Ghaemi M, Ataei-Pirkooh A, Motamedaria P, Hemmasi G, Motevasselian M, Panahi Z, Karbalaie Niya MH   +8 more
doaj  

Association between physical activity and vitamin D status: A cross-sectional study from the PERSIAN Guilan cohort study

Journal of Current Biomedical Reports
A surprisingly high prevalence of vitamin D (vit D) deficiency has recently been reported worldwide. This study investigated the association between vit D status and physical activity in the Prospective Epidemiological Research Studies in IRAN (PERSIAN ...
Mohammadreza Javid, Farahnaz Joukar, Amirreza Emamhadi, Niloofar Faraji, Tahereh Zeinali, Saman Maroufizadeh, Mohammadreza Naghipour, Fariborz Mansour-Ghanaei   +7 more
doaj   +1 more source

The evolving role of MRI in the detection of extrathyroidal extension of papillary thyroid carcinoma: a systematic review and meta-analysis

BMC Cancer
Background Papillary thyroid carcinoma (PTC) is the predominant form of thyroid cancer, and the presence of extrathyroidal extension (ETE) significantly impacts treatment decisions and prognosis. Accurate preoperative detection of ETE remains challenging,
Mona Javid, Arian Mirdamadi, Mohammadreza Javid, Mohammad-Hossein Keivanlou, Ehsan Amini-Salehi, Naeim Norouzi, Elahe Abbaspour, Ahmad Alizadeh, Farahnaz Joukar, Fariborz Mansour-Ghanaei, Soheil Hassanipour   +10 more
doaj   +1 more source