Results 61 to 70 of about 10,687,454 (378)

First reports of esophageal adenocarcinoma with white globe appearance in Japanese and Caucasian patients

Endoscopy International Open, 2016
Background and study aims: Better endoscopic diagnosis in case of Barrett’s esophagus is still needed. White globe appearance (WGA) is a novel endoscopic marker for gastric adenocarcinoma, with high sensitivity for differentiating between gastric cancer ...
Yusuke Tonai, Ryu Ishihara, Yasushi Yamasaki, Takashi Kanesaka, Sachiko Yamamoto, Tomofumi Akasaka, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Yasuhiko Tomita, Hiroyasu Iishi   +11 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population

BMC Endocrine Disorders
Background Waist circumference (WC), or waist-to-hip ratio (WHR), potentially offers a more accurate reflection of intra-abdominal fat accumulation and could serve as a superior predictor of type 2 diabetes mellitus (T2DM) risk compared to BMI.
Masoome Aghaei, Farahnaz Joukar, Soheil Hasanipour, Zahra Abbasi Ranjbar, Mohammadreza Naghipour, Fariborz Mansour-Ghanaei   +5 more
doaj   +1 more source

Prognostic significance of pretreatment plasma fibrinogen level in patients with digestive system tumors: a meta-analysis

The International Journal of Biological Markers, 2018
High pretreatment levels of plasma fibrinogen have been widely reported to be a potential predictor of prognosis in digestive system tumors; however, the conclusions are not consistent.
Rui Ji, Qian Ren, Suyang Bai, Yuping Wang, Yongning Zhou   +4 more
doaj   +1 more source

Favorable association between Mediterranean diet (MeD) and DASH with NAFLD among Iranian adults of the Amol Cohort Study (AmolCS)

Scientific Reports, 2022
Nonalcoholic fatty liver disease (NAFLD) is an emerging cause of chronic liver diseases and a major health problem worldwide. Dietary patterns may play a critical role in controlling and preventing this disease, but the available evidence is scarce.
Azam Doustmohammadian, Cain C. T. Clark, Mansooreh Maadi, Nima Motamed, Elham Sobhrakhshankhah, Hossein Ajdarkosh, Mohsen Reza Mansourian, Saeed Esfandyari, Nazanin Asghari Hanjani, Mahsa Nikkhoo, Farhad Zamani   +10 more
doaj   +1 more source

Risk factors associated with the occurrence of autoimmune diseases in adult coeliac patients [PDF]

, 2018
Objectives. Autoimmune diseases (AD) may be associated with coeliac disease (CD), but specific risk factors have been poorly investigated. The aim of this study was to assess the spectrum of AD and its specific risk factors associated in a series of ...
Annibale, Bruno, Carabotti, Marilia, Conti, Laura, Esposito, Gianluca, Galli, Gloria, Lahner, Edith   +5 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Opportunity Costs of Gastrointestinal Endoscopic Training in Canada

Canadian Journal of Gastroenterology, 2010
BACKGROUND: No data exist to define the opportunity costs related to instruction in endoscopic procedures in Royal College of Physicians and Surgeons of Canada-accredited teaching centres. Academic and institutional administrators expect staff to achieve
WT Depew, LC Hookey, SJ Vanner, JA Louw, CE Lowe, MJ Ropeleski, MJ Beyak, A Lazarescu, WG Paterson   +8 more
doaj   +1 more source

The diagnostic value of non-invasive serum liver fibrosis indices in the prediction of portal hypertension in cirrhotic patients: a cross-sectional study [PDF]

Journal of Research in Clinical Medicine, 2020
Introduction: Considering that portal hypertension is principally caused by hepatic fibrosis, some studies postulated the predictive value of serum liver fibrosis indices in the diagnosis of portal hypertension.
Masood Faghih Dinevari, Mohammad Hossein Somi, Mohammad Kazem Tarzamni, Leila Alizadeh, Samaneh Abbasian, Ali Riazi, Zeinab Nikniaz   +6 more
doaj   +1 more source

Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. [PDF]

, 2019
Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions ...
Akiba, Yasutada, Iwasaki, Mari, Kaunitz, Jonathan D   +2 more
core