Results 81 to 90 of about 10,687,454 (378)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Adhesive Properties and Sensitivity to Antifungal Drugs of Candida Albicans, Which Are Released From Patients of Gastroenterological Profile with Candidiasis of the Mucosa of the Upper Part of the Digestive Tract [PDF]

, 2016
Candida albicans were released from 146 loci from 89 patients in order to perform the investigation. The fourth stage of contamination by Candida albicans in the scrape from the tongue and candidiasis of the esophagus or /and the stomach during ...
Kushnirenko, I. (Inessa)
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Recurrent Gastrointestinal Bleeding in a Man with Osler-Weber-Rendu Syndrome and Intestinal Varices

Canadian Journal of Gastroenterology, 1988
A patient with Osler-Weber-Rendu disease and idiopathic intestinal varices who presented with recurrent gastrointestinal hemorrhage and iron deficiency anemia is reported. The unique coexistence of these two rare disorders is discussed and the literature
Robert N. Clark, William G. Paterson, Laurington R. DaCosta, Ivan T. Beck   +3 more
doaj   +1 more source

Autoimmune gastrointestinal complications in patients with Systemic Lupus Erythematosus: case series and literature review [PDF]

, 2016
The association of systemic lupus erythematosus (SLE) with gastrointestinal autoimmune diseases is rare, but has been described in the literature, mostly as case reports.
Agmon-Levin N, Ahmed QM, Akram S, Arnett FC, Bessone F, Breuer GS, Byun JY, Cabrera GE, Carmona-Fernandes D, Carone FA, Chebli JM, Chong WP, Chowdhary VR, Cortese AF, Cowling DC, Criş cov GI, Culp KS, D A Isenberg, De Jager PL, Denham JM, Dreiling DA, Dubois EL, Ebert EC, Efe C, Efe C, Einarsdottir E, Essaadouni L, Fernández Rodríguez AM, Ferreiros-Vidal I, Fina D, Floreani A, Freeman HJ, Gershwin ME, Gibson T, Grimbacher B, Gupta D, Hallegua DS, Hamed I, Han S, Harada K, Hennes EM, Her M, Homberg JC, Irving KS, Isenberg DA, Janssens P, Joske RA, Ju JH, Kapila N, Katsanos KH, Katsanos KH, Laing TJ, Lee C-K, Leggett BA, Leonard WJ, Levy C, Lohse AW, Ludvigsson JF, Mackay IR, Makol A, Matsumoto T, Medina F, Michalopoulos G, Miller MH, Miyazaki T, Muratori P, Nakou M, Nesher G, Netto AP, Nitzan O, Park SW, Pascual-Ramos V, Pisetsky DS, Pollak VE, Reifenstein EC, Rensch MJ, Reynolds JC, Rodriguez EA, Runyon BA, Rustgi AK, S Custódio Alves, S Fasano, Seelig R, Serrano López MC, Shapeero LG, Shizuma T, Shizuma T, Sparberg M, Steffan W, Sultan SM, Sánchez-Guerrero J, Takahashi A, Taourel P, Thomas JR, Tian X-P, van Hoek B, Vergani D, Vitali C, Yamashita H, Zheng R-H, Zizic TM, Zizic TM   +101 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Bacteriocins and Bacteriophages: Therapeutic Weapons for Gastrointestinal Diseases?

International Journal of Molecular Sciences, 2019
Bacteriocins are bactericidal peptides, ribosomally synthesized, with an inhibitory activity against diverse groups of undesirable microorganisms. Bacteriocins are produced by both gram-positive and gram-negative bacteria, and to a lesser extent by some ...
L. Lopetuso, Maria Ernestina Giorgio, Angela Saviano, F. Scaldaferri, A. Gasbarrini, G. Cammarota   +5 more
semanticscholar   +1 more source

Rectal bleeding as a symptom of solitary rectal ulcer syndrome mimicking rectal neoplasm on colonoscopy: A case report

Clinical Case Reports, 2023
Key Clinical Message Patients complaining of rectal bleeding, constipation, and a suspicious mass in colonoscopy should undergo biopsy. Histological features such as fibromuscular obliteration in the lamina propria favor SRUS, a benign disorder.
Masood Faghih Dinevari, Amirtaher Eftekharsadat, Mahdi Tarverdizadeh, Seyyed Mahdi Rasulimanesh, Ali Riazi, Amirreza Jabbaripour Sarmadian, Samaneh Abbasian   +6 more
doaj   +1 more source

Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]

, 2013
Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D, Falk, Gary W, Hartman, Kira G, Lynch, John P, Martín, Martín G, Rustgi, Anil K, Yu, Jian   +6 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source