Results 61 to 70 of about 480,848 (312)

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Rebleeding rate after interventional therapy directed by capsule endoscopy in patients with obscure gastrointestinal bleeding [PDF]

, 2008
Background The precise role of capsule endoscopy in the diagnostic algorithm of obscure gastrointestinal bleeding has yet to be determined. Despite the higher diagnostic yield of capsule endoscopy, the actual impact on clinical outcome remains poorly ...
Hiroki Endo, Kantaro Hisatomi, Fujita Koji, Teratani Takuma, Masako Asayama, Akimoto Keiko, Hisatomi Kantaro, Nobuyuki Matsuhashi, Inamori Masahiko, Yanagawa Tatsuro, Yoneda Masato, Asayama Masako, Tomohiko Ohya, Masato Yoneda, Atsushi Nakajima, Nakajima Atsushi, Masahiko Inamori, Takuma Teratani, Tatsuro Yanagawa, Matsuhashi Nobuyuki, Ohya Tomohiko, Endo Hiroki, Koji Fujita, Keiko Akimoto   +23 more
core   +2 more sources

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

A simple scoring system to estimate adenoma detection rate from polyp detection: a two-center observational study

BMC Gastroenterology
Purpose The calculation of adenoma detection rate (ADR) requires pathological information, which makes it time-consuming. We aimed to develop a scoring system to estimate ADR from polyp detection accurately.
Zhiyu Dong, Yanglei Li, Zili Xiao, Feng Li, Shuchang Xu, Danian Ji   +5 more
doaj   +1 more source

The Role of Rapid Endoscopy for High-Risk Patients with Acute Nonvariceal Upper Gastrointestinal Bleeding [PDF]

, 2007
BACKGROUND: Performance of endoscopy within 24 h is recommended for patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB). It is unknown whether performing endoscopy early within this 24 h window is beneficial for clinically high-risk
Laura E Targownik, Shauna Leeson, Sanjay Murthy, Leila Keyvani, Keyvani, Leila, Leeson, Shauna, Targownik, Laura E, Murthy, Sanjay   +7 more
core   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Efficacy and safety of cap-assisted endoscopic mucosal resection for superficial duodenal epithelial neoplasia ≤ 10 mm

Endoscopy International Open, 2023
Yoshiaki Kimoto, Rikimaru Sawada, Susumu Banjoya, Toshifumi Iida, Tomoya Kimura, Koichi Furuta, Shinya Nagae, Yohei Ito, Hiroshi Yamazaki, Nao Takeuchi, Shunya Takayanagi, Yuki Kano, Takashi Sakuno, Kohei Ono, Ryoju Negishi, Akiko Ohno, Eiji Sakai, Yohei Minato, Hideyuki Chiba, Ken Ohata   +19 more
doaj   +1 more source

A Preclinical Multifunctional Capsule Robot with Unified Diagnosis and Targeted Thermal Therapy for Gastrointestinal Diseases

Advanced Science, EarlyView.
A proof‐of‐concept multifunctional capsule robot integrates diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy for gastrointestinal applications. Magnetically guided positioning and stable wireless power enable localized thermal ablation, achieving controlled heating and high cell mortality in vitro.
Heng Zhang, Yichong Sun, Xiaoting Zhang, Chi‐Kwan Lee, Zheng Li, Yehui Li, Huarong Chen, Paul D. Mitcheson   +7 more
wiley   +1 more source

Current status of advanced gastrointestinal endoscopy training fellowships in the United States

, 2011
Stephen J Heller, Jeffrey L TokarDepartment of Medicine, Fox Chase Cancer Center, Philadelphia, PA, USAAbstract: Rapid growth in the field of advanced gastrointestinal endoscopy has led to an increase in specialized therapeutic endoscopy fellowships. The
Stephen J Heller, Jeffrey L Tokar
core  

Use of lower gastrointestinal endoscopy and fecal occult blood test in the 2007 Swiss Health Interview Survey respondents aged 50 years and older [PDF]

, 2013
Background and study aims: Colorectal cancer (CRC) incidence ranks third among all cancers in Switzerland. Screening the general population could decrease CRC incidence and mortality. The aim of this study was to analyze the use of the fecal occult blood
Spaeth, A., Zwahlen, M., Späth, A., Spaeth A, Zwahlen M   +4 more
core   +1 more source