Results 71 to 80 of about 111,491 (300)

Obscure Gastrointestinal Bleeding: An Approach to Management

Canadian Journal of Gastroenterology, 2000
Obscure gastrointestinal bleeding provides an uncommon but frustrating and resource-intensive challenge for clinicians. Such patients hemorrhage recurrently from sites within the gastrointestinal tract that are not detected by routine endoscopy or ...
JK Marshall, OA Lesi, RH Hunt
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Treatment of gastrointestinal hemorrhage [PDF]

, 2018
Background: We assessed the value of selective arteriography in the diagnosis and management of acute gastrointestinal hemorrhage. Methods: We reviewed the records of 107 consecutive patients who had gastrointestinal hemorrhage and underwent selective ...
Toman, J., Charbonnet, P., Becker, C., Vermeulen, B., Morel, P., Terrier, F., Bühler, L.   +6 more
core  

Gastrointestinal hemorrhage after concurrent chemoradiotherapy in locally advanced pancreatic cancer [PDF]

, 2013
BACKGROUND/AIMS: While chemoradiotherapy (CRT) is considered to be a reasonable treatment for locally advanced pancreatic cancer (LAPC), there is little information about the associated risk of gastrointestinal (GI) hemorrhage.
박승우, 박정엽, 방승민, 송시영, 이우정, 정문재, 성진실   +6 more
core   +3 more sources

Acute Gastrointestinal Bleeding Caused by Dieulafoy Lesion of the Esophagus

Acta Médica Portuguesa, 2017
N/A.
Armando Peixoto, Regina Gonçalves, Guilherme Macedo   +2 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Embolization for Management of Acute Non-variceal Gastrointestinal Hemorrhage [PDF]

, 2016
This section provides a comprehensive procedural report for embolization for management of acute non-variceal gastrointestinal hemorrhage procedure with up-to-date explanatory notes, synopsis of the indications and contraindications, and potential ...
Anne M. Covey, Covey, Anne M.
core   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Gastrointestinal hemodynamics during compensation for hemorrhage and measurement of Pmcf [PDF]

, 1994
To quantify the degree of autonomic reflex control of the gastrointestinal vasculature, we studied the responses to a 10-ml/kg hemorrhage or transfusion and autonomic blockade in fentanyl- and pentobarbital-anesthetized dogs.
R. Maass-Moreno, C. F. Rothe
core   +1 more source

Comparison of outcomes of direct oral anticoagulants versus vitamin K antagonists for atrial fibrillation and chronic kidney disease: a systematic review and meta-analysis

International Journal of Cardiology. Cardiovascular Risk and Prevention
Objective: To systematically evaluate the efficacy and safety of direct oral anticoagulants (DOAC) compared to vitamin K antagonists (VKA) for anticoagulation in patients with atrial fibrillation (AF) and chronic kidney disease (CKD).
Bing Luo, Yueyun Jiang, Minyi Tan, Jingyan Yang, Yue Fan, Yili Chen   +5 more
doaj   +1 more source