Results 221 to 230 of about 320,222 (355)

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao   +11 more
wiley   +1 more source

Efficacy of a real-time intelligent quality-control system for the detection of early upper gastrointestinal neoplasms: a multicentre, single-blinded, randomised controlled trial. [PDF]

open access: yesEClinicalMedicine
Zhou R   +21 more
europepmc   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

open access: yesAdvanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng   +8 more
wiley   +1 more source

Endoscopic Ultrasound (EUS)-Guided Tissue Acquisition and Histomorphologic Analysis for Suspected Spindle Cell Neoplasms of the Upper Gastrointestinal Tract: Does the Needle Size and Type Matter?

open access: diamond
Hemanta Kumar Nayak   +9 more
openalex   +1 more source

Genomic dissection of gastrointestinal and lung neuroendocrine neoplasm

open access: diamond, 2019
Haixing Wang   +11 more
openalex   +2 more sources

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang   +16 more
wiley   +1 more source

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