Results 41 to 50 of about 154,232 (303)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Stromal tumor of the lesser omentum: a case report

The Pan African Medical Journal, 2014
Gastrointestinal stromal tumors (GISTs) represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein detected by immunohistochemical staining for the CD117 antigen.
Hossam Behammane, Younes Aggouri, Morad Oussaid, Said Ait Laalim, Imane Toughrai, Karim Ibn majdoub, Khalid Mazaz   +6 more
doaj   +1 more source

Significance of the Glasgow prognostic score for short‐term surgical outcomes: A nationwide survey using the Japanese National Clinical Database

Annals of Gastroenterological Surgery, 2021
Aim Preoperative inflammation‐based Glasgow prognostic score (GPS) is a useful tool for predicting long‐term prognosis in cancer patients. However, its association with postoperative short‐term outcomes remains unknown.
Yoshihiro Hiramatsu, Hiraku Kumamaru, Hirotoshi Kikuchi, Shiyori Usune, Kinji Kamiya, Hiroaki Miyata, Hiroyuki Konno, Yoshihiro Kakeji, Yuko Kitagawa, Hiroya Takeuchi   +9 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Epidemiology of gastrointestinal proliferative neoplastic-like lesions and tumors in dogs and cats: a retrospective study in two Romanian reference laboratories

Cluj Veterinary Journal
Gastrointestinal neoplasms are rare in dogs and cats, primarily comprising adenocarcinomas, lymphomas, leiomyomas, leiomyosarcomas, and gastrointestinal stromal tumors (GISTs). In the current literature  epidemiological data  are scars. The aim of  this
Andrada Negoescu, Cristina-Diana Borfalău, Claudiu Gal, Marian Taulescu, Cornel Cătoi   +4 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Quantifying the impact of the COVID‐19 pandemic on gastrointestinal cancer care delivery

Cancer Reports, 2022
Background and Aim This study quantifies how changes in healthcare utilization and delivery during the first months of the COVID‐19 pandemic have altered the presentation, treatment, and management of patients with gastrointestinal (GI) malignancies ...
Nicholas R. Perkons, Casey Kim, Chris Boedec, Luke J. Keele, Charles Schneider, Ursina R. Teitelbaum, Edgar Ben‐Josef, Peter E. Gabriel, John P. Plastaras, Lawrence N. Shulman, Andrzej P. Wojcieszynski   +10 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Site‐specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany

Cancer Medicine, 2023
Introduction Neuroendocrine neoplasms (NEN) are rare and heterogeneous epithelial tumors, occurring throughout the body. For gastroenteropancreatic (GEP)‐NEN, rising incidence rates were reported for the last decades, with underlying causes remaining ...
Nina Grundmann, Sven Voigtländer, Amir Hakimhashemi, Ulrich‐Frank Pape, Martin Meyer, Jacqueline Müller‐Nordhorn   +5 more
doaj   +1 more source