Results 61 to 70 of about 686,087 (300)

Gastrointestinal stromal tumors and concomitant neoplasms [PDF]

, 2016
Gastrointestinalni stromalni tumori (GIST) najčešći su mezenhimalni tumori probavnoga trakta. Najčešće se javljaju sporadično. Unatoč tome, drugi primarni tumori kod bolesnika s GIST-om nisu rijetkost. Ovi se tumori mogu pojaviti u isto vrijeme (sinkrono)
Krstanac, Karolina
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Imatinib-Resistant Gastrointestinal Stromal Tumor Presenting as a Large Abdominal Mass

Case Reports in Gastroenterology, 2021
Gastrointestinal stromal tumors (GISTs) are the stromal or mesenchymal neoplasms affecting the gastrointestinal tract. Although they constitute 1% of primary gastrointestinal tumors, they are the most common nonepithelial tumors involving the ...
Asim Haider, Shehriyar Mehershahi, Ayesha Siddiqa, Madhav Sharma, Harish Patel   +4 more
doaj   +1 more source

Gynaecological or gastrointestinal origin? Recognising Mullerian neoplasms with gastrointestinal phenotype and determining the primary site in selected entities

, 2022
Recognising metastatic gastrointestinal and pancreatobiliary tumours to gynaecological sites may be challenging, as primary Mullerian tumours can demonstrate similar histological features.
Pinto, Andre, Ronquillo, Nemencio
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Gastrointestinal Cancers

, 2022
Gastrointestinal cancers represent a heterogeneous group of diseases of the gastrointestinal tract. There is an interplay of various non-modifiable and modifiable risk factors that foster the conversion of normal cells to precursor cells, precursor cells

core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Acute intestinal obstruction revealing synchronous gastrointestinal stromal tumors in a small bowel diverticulum and mucinous adenocarcinoma of the colon: a case report

The Pan African Medical Journal, 2015
Gastrointestinalstromal tumors are rare neoplasms and represent 0,1% to 3% of all gastrointestinal cancers. They are the most frequent mesenchymal neoplasms of the gastrointestinal tract with a malignant potential and unpredictable behavior.
El Ochi Mohamed Reda, Jahid Ahmed, El Ktaibi Abderrahim, Znati Kawtar, Zouaidia Fouad, Bernoussi Zakia, Mahassini Najat   +6 more
doaj   +1 more source

Calcifying Fibrous Tumor of the Jejunum in a 27-year-old Primigravid

Philippine Journal of Pathology, 2020
The most common mesenchymal tumors of the gastrointestinal tract are gastrointestinal stromal tumors (GIST) and smooth muscle neoplasms; however, other soft tissue tumors may also present in the intestines and cause diagnostic dilemmas.
Marvin Masalunga, Jose Carnate Jr.
doaj   +1 more source