Results 71 to 80 of about 2,259,874 (301)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Sleep disturbances and psychological factors as mediators between gastrointestinal symptoms and disease severity in chronic spontaneous urticaria

World Allergy Organization Journal
Background: Dysregulation of gastrointestinal function has been implicated in the pathogenesis of chronic spontaneous urticaria (CSU). Moreover, persistent wheals and pruritus in CSU are frequently accompanied by sleep disturbances and psychological ...
Hongshan Liu, MD, Yuxin Ma, MD, Xinxuan Li, MD, Luyue Zhang, MD, Chunzhi Qi, MD, Ziyun Gao, MD, Weihui Zeng, MD, Zhao Wang, MD   +7 more
doaj   +1 more source

Population-based assessment of gastrointestinal symptoms and diseases: Cappadocia Cohort, Turkey

The Turkish Journal of Gastroenterology, 2019
Background/Aims: The aim of this study was to determine the prevalence of symptoms and diseases of the lower and upper gastrointestinal system (GIS) in a population-based sample.
Orhan Sezgin, Hale Akpınar, Birol Özer, Murat Törüner, Kadir Bal, Serhat Bor   +5 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Dyspeptic Symptoms In Type 2 Diabetes Patients [PDF]

Liaquat National Journal of Primary Care
Background: Nearly half of the patients with diabetes experience diabetic gastroparesis. Some diabetic patients present with complaints of epigastric pain, vomiting, nausea, or postprandial fullness, however only a few have severe symptoms.
Annum Rahim, Muhammad Fahad Zakir, Fasiha Mazhar, Umer Jehangir, Misbah Patoli, Faisal Ziauddin   +5 more
doaj   +1 more source

Gastrointestinal Symptoms in ASD Study Population.

, 2013
Gastrointestinal Symptoms in ASD Study Population.
John Fortunato (387163), Arthur Krigsman (387165), Lenny G. Gonzalez (387164), Stephen J. Walker (387162)   +3 more
core   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Prevalence of gastrointestinal symptoms after recovery from COVID-19: A questionnaire-based study in the Aseer region

SAGE Open Medicine
Background: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide, and although it is primarily a respiratory illness, gastrointestinal symptoms have been reported in a significant proportion of patients.
Mohammed Attieh Alzahrani, Khalid Siraj Altalhiyyah, Mohammed Mousa Albariqi, Meshal Ali Alkhayri, Saad Ali Alshahrani, Sultan Saad Alnasser, Nawaf Mohammed Alshehri, Saad Haif Alqahtani, Saud Haif Alqahtani   +8 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Gluten-free diet adherence patterns and health outcomes in celiac disease: a retrospective observational study

BMC Gastroenterology
Background Celiac disease (CeD) is an autoimmune disorder, causing significant gastrointestinal (GI) and non-GI symptoms. The only effective treatment is a gluten-free diet (GFD), but adherence can be challenging.
Saba Rahimi, Mohadeseh Mahmoudi Ghehsareh, Nastaran Asri, Mehdi Azizmohammad Looha, Somayeh Jahani-Sherafat, Carolina Ciacci, Mohammad Rostami-Nejad   +6 more
doaj   +1 more source