Results 111 to 120 of about 1,251,513 (308)

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Validation of the Persian version of the inflammatory bowel disease questionnaire (IBDQ) in ulcerative colitis patients

Caspian Journal of Internal Medicine, 2015
Background: Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine that may have critical consequences on patient’s quality of life (QOL). Many disease-specific QOL tools have been developed recently.
Iradj Maleki, Tarang Taghvaei, Maryam Barzin, Kamyar Amin, Alireza Khalilian   +4 more
doaj  

Subcutaneous Pedicle Advancement Flap Anoplasty with Pivot Point Medialization for Anal Stenosis: A Single-center Retrospective Study

Journal of the Anus, Rectum and Colon
Objectives: Severe anal stenosis, particularly Whitehead deformity, presents a significant reconstructive challenge. This study reports the clinical outcomes of a modified subcutaneous pedicle advancement flap anoplasty emphasizing pivot point ...
Naoki Yago, Masami Saito, Hiroki Yago
doaj   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

ZNF114 as a prognostic biomarker associated with Wnt/EMT and immune-related features in gastric cancer

Frontiers in Oncology
ObjectiveTo investigate ZNF114 expression, clinical significance, and its role in malignant phenotypes and its associations with immune-related features in gastric cancer (GC).MethodsZNF114 expression and prognosis were analyzed using The Cancer Genome ...
Wenzheng Li, Wenzheng Li, Zhengxuan Zhang, Zhengxuan Zhang, Yiyan Li, Yiyan Li, Aoxue Xing, Aoxue Xing, Hailiang Wang, Hailiang Wang, Gang Wu, Gang Wu, Peichun Sun, Peichun Sun, Wei Zhang, Wei Zhang, Wei Zhang   +16 more
doaj   +1 more source

Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis

Advanced Science, EarlyView.
A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu, Priyanka G. Bhosale, Vishal Kumar, Jeyrroy Gabriel, Shiyue Liu, Ciro Chiappini, Richard J. Cook, Mads S. Bergholt   +7 more
wiley   +1 more source

Cancers of the gastrointestinal tract

, 2010
Cancers of the gastrointestinal tract are one of the most rewarding interfaces in translational medicine—particularly on colorectal cancer—leading to greater understanding of the genetic mechanisms leading to cancer and the development of novel targeted ...
J.A. Bridgewater, S.P. Pereira
core   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Comparative study of ICG and non-ICG-guided laparoscopic gastrectomy for gastric cancer: a propensity score-matched analysis at a single center

BMJ Surgery, Interventions, & Health Technologies
Objectives To investigate the effectiveness of indocyanine green (ICG) lymphography in improving lymph nodes (LNs) harvesting during laparoscopic radical distal gastrectomy for gastric cancer.Design Non-randomized trial, prospective study compared ICG ...
Nguyen Anh Tuan, Nguyen Van Du, Luong Ngoc Cuong   +2 more
doaj   +1 more source

The impact of asthma on the gastrointestinal tract (GIT) [PDF]

, 2010
Warren Antonio Vieira, Etheresia PretoriusDepartment of Anatomy, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South AfricaAbstract: The gastrointestinal tract (GIT) of vertebrates is composed of several distinct & ...
Vieira, Warren Antonio, Etheresia Pretorius, Pretorius, Etheresia, Warren Antonio Vieira   +3 more
core