Results 201 to 210 of about 5,047 (245)

Gastroprotection during long-term dual antiplatelet therapy: to give or not to give?

Journal of Geriatric Cardiology, 2021
Dear Editor, We read with interest Kim J, et al. titled “Potentially inappropriate prescribing of cardiovascular system and antiplatelet/anticoagulant drugs among elderly patients: a Korean population-based national study” highlighting that the more ...
F. Sbrana, A. Ripoli, B. Pino
semanticscholar   +1 more source

Pharmacological gastroprotection: Indications, possibilities and risks

Meditsinskiy sovet = Medical Council
The article is an analytical review of the concept of pharmacological gastroprotection. The authors emphasize that the integrity of the gastric mucosa is maintained due to a complex balance between the factors of aggression (hydrochloric acid, pepsin ...
S. Serebrova, A. B. Prokofiev, E. Y. Esakova, M. V. Zhuravleva, N. Eremenko, R. E. Kazakov   +5 more
semanticscholar   +1 more source

Mechanisms of Gastroprotection

Scandinavian Journal of Gastroenterology, 1990
Gastric mucosa is constantly exposed to various irritants, but it usually maintains its integrity owing to several lines of defense, including mucus-alkaline secretion, mucosal hydrophobicity, rich mucosal blood flow, stabilization of tissue lysosomes, maintenance of mucosal sulfhydryls, and rapid proliferation and renewal of mucosal cells ...
openaire   +2 more sources

Gastroprotective and Antisecretory Effects of Ebrotidine

Scandinavian Journal of Gastroenterology, 1992
This study was designed to assess the gastroprotective and secretory effects of ebrotidine, a novel H2-receptor antagonist, in humans. Two groups (A and B) of male subjects with normal gastric mucosa were used. Group A (six subjects) was treated for 3 days with either ebrotidine or placebo in a randomized, crossover study, and on the 4th day 100 ml of ...
S J, Konturek, J, Maczka, K, Kaminski, E, Sito, J, Torres, J, Oleksy   +5 more
openaire   +2 more sources

An Intervention to Reduce Antiplatelet Use without Gastroprotection in Patients Using Warfarin: The AEGIS Cluster Randomized Trial

Thrombosis and Haemostasis
Background Many patients receiving anticoagulants take antiplatelet medications unnecessarily and without gastroprotection, increasing the risk of gastrointestinal bleeding.
Jacob E Kurlander, Danielle Helminski, Xueting Tao, Sameer D. Saini, Sarah L. Krein, Caroline R. Richardson, K. Kidwell, M. Lanham, Jennifer L. Henstock, J. Resnick, M. Song, R. D. Vries, Kenneth Resnicow, Nghi Ha, B. Haymart, Constantina Alexandris-Souphis, James B. Froehlich, Geoffrey D. Barnes   +17 more
semanticscholar   +1 more source

Structural characteristics of a purified Evodiae fructus polysaccharide and its gastroprotection and relevant mechanism against alcohol-induced gastric lesions in rats.

International Journal of Biological Macromolecules
Evodiae fructus polysaccharide (EFP) has been previously shown to protect against alcohol-induced gastric lesions. However, which and how active fractions in EFP exert gastroprotection remains unclear.
Xiaoyu Wang, Ming Hao, Yan-Ping Li, Jun Zhang, Quan-Sheng Xu, Fan Yang, Zi-Chao Yang, Yu Xiong, Er-Sheng Gong, Jiang-Hong Luo, Qi Zou   +10 more
semanticscholar   +1 more source

Gastroprotective mechanism of Bauhinia thonningii Schum

Journal of Ethnopharmacology, 2013
Bauhinia thonningii Schum. (Cesalpiniaceae) is locally known as Tambarib and used to treat various diseases including gastric ulcer.The current study aims to evaluate the gastroprotecive mechanism(s) of methanolic (MEBT) and chloroform (CEBT) extracts of Bauhinia thonningii leaves on ethanol-induced gastric ulceration.Gastric acidity, quantification ...
Abdelwahab, S.I., Taha, M.M.E., Abdulla, M.A., Nordin, N., Hadi, A.H.A., Mohan, S., Jayapalan, J.J., Hashim, Onn Haji   +7 more
openaire   +3 more sources

In situ triggered, floating delivery systems of capsaicin for prolonged gastroprotection.

European journal of pharmaceutics and biopharmaceutics
Capsaicin (CAP) has been implicated as a gastroprotective agent in the treatment of peptic ulcers. However, its oral administration is hampered by its poor aqueous solubility and caustic effect at high administered doses. To address these limitations, we
Konstantina Chachlioutaki, P. D. Prazeres, Sérgio R A Scalzo, Pelagia Bakirtzi, Samson Afewerki, P. T. G. Guimarães, N. Bouropoulos, D. Fatouros, C. Karavasili   +8 more
semanticscholar   +1 more source

Cyclooxygenase Inhibition Attenuates Cholecystokinin-Induced Gastroprotection

Digestive Diseases and Sciences, 1998
Cholecystokinin prevents gastric injury by an unknown mechanism. This study was conducted in conscious, fasted female rats in order to assess the role of endogenous prostaglandins as a potential protective mechanism for cholecystokinin-induced gastroprotection.
D W, Mercer, G S, Smith, T A, Miller
openaire   +2 more sources

Gastroprotective Effect and Cytotoxicity of Labdenamides

Planta Medica, 2007
Some 18 aromatic amides from the labdane diterpenes 15-acetoxyimbricatolic acid and 15-acetoxylabd-8(9)-en-19-oic acid were prepared and assessed for their gastroprotective effect in the HCl/EtOH-induced gastric lesion model in mice. The analysis of the gastroprotective activity of the benzylamides belonging to the series 8(9)- and 8(17)-ene was ...
Izquierdo, R.A., Astudillo, L., Rodriguez, J., Theoduloz, C., Palenzuela, J.A., Schmeda-Hirschmann, G.   +5 more
openaire   +2 more sources