The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]
, 2012 Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
A Quintas-Cardama +39 more
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GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism. [PDF]
PLoS ONE, 2013 Lipopolysaccharide (LPS) is a critical factor for inducing acute lung injury. GATA-2, a transcription factor, contributes to the control of cell activity and function.
Tsu-Tuan Wu +7 more
doaj +1 more source
Isolation and characterization of microsatellite loci from two inbreeding bark beetle species (Coccotrypes) [PDF]
, 2003 We developed 14 microsatellite markers in Coccotrypes carpophagus and 14 in C. dactyliperda. These loci will be used for studying genetic structure and the level of inbreeding in populations in the Canary Islands and Madeira.
Armour JAL +9 more
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RUDN journal of SociologyThe generalization of the results accumulated to date has shown that the implicit measures of attitudes (some even suggest defining them with a less pretentious term “indirect”) show a disappointingly weak predictive potential in relation to real ...
O. L. Chernozub
doaj +1 more source
Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice [PDF]
, 2001 The zinc finger transcription factor GATA-3 is of critical importance for early T cell development and commitment of Th2 cells.
Dingjan, G.M. (Gemma) +7 more
core +4 more sources
Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia trachomatis Elicits Robust Type 2 Immunity [PDF]
, 2013 While Chlamydia trachomatis infections are frequently asymptomatic, mechanisms that regulate host response to this intracellular Gram-negative bacterium remain undefined.
AL Graham +42 more
core +3 more sources
Psychiatry and Behavioral Sciences, 2016 Neuroleptic Malignant Syndrome (NMS); is a rare, idiosyncratic adverse reaction which usually occurs with antipsychotic treatment. It is defined as fever, autonomic instability, extrapyramidal syndrome and altered mental state.
Mustafa İspir +7 more
doaj +1 more source
A Multi-Temporal Object-Based Image Analysis to Detect Long-Lived Shrub Cover Changes in Drylands [PDF]
, 2019 Climate change and human actions condition the spatial distribution and structure of vegetation, especially in drylands. In this context, object-based image analysis (OBIA) has been used to monitor changes in vegetation, but only a few studies have ...
Alcaraz Segura, Domingo +4 more
core +6 more sources
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]
, 2013 IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M, Smith, Katherine A
core +2 more sources