Results 81 to 90 of about 1,580,633 (289)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

P-channel silicone gate FET [PDF]

, 1973
Modified fabrication technique for P-channel MOSFET devices eliminates problems involving gate placement and gate overlap. Technique provides self-aligned gate, eliminating complexity of mask aligning.
Ostis, S., Woo, D. S.
core   +1 more source

Exact solutions of the isoholonomic problem and the optimal control problem in holonomic quantum computation

, 2004
The isoholonomic problem in a homogeneous bundle is formulated and solved exactly. The problem takes a form of a boundary value problem of a variational equation. The solution is applied to the optimal control problem in holonomic quantum computer.
Guichardet A., Iwai T., Kobayashi S., Marsden J. E., Messiah A., Nakahara M., Niskanen A. O.   +6 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Study of Parameters Affecting Breakdown Voltage of Bipolar Static Induction Transistor

Известия высших учебных заведений России: Радиоэлектроника, 2017
The article considers structural and technological parameters affecting breakdown voltage of a BSIT transistor cell. The main objective of the scientific research in that field is optimization of manufacturing techniques of power electronics transistor ...
T. A. Ismailov, A. R. Shakhmaeva, B. A. Shangereeva   +2 more
doaj  

Capacitive Spring Softening in Single-Walled Carbon Nanotube Nanoelectromechanical Resonators

, 2010
We report the capacitive spring softening effect observed in single-walled carbon nanotube (SWNT) nanoelectromechanical (NEM) resonators. The nanotube resonators adopt dual-gate configuration with both bottom-gate and side-gate capable of tuning the ...
Babic B., Chiu H. Y., Chung Chiang Wu, Cleland A. N., Dresselhaus M. D., Fung W. Y., Garcia-Sanchez D., Hierold C., Karabalin R. B., Kis A., Kong J., Kozinsky I., Krishnan A., Lassagne B., Lu J. P., Peng H. B., Sapmaz S., Sazonova V., Steele G. A., Unterreithmeier Q. P., Ustunel H., Witkamp B., Wu C. C., Zhang Y. Y., Zhaohui Zhong   +24 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Formation of p-n junction in polymer electrolyte-top gated bilayer graphene transistor

, 2009
We show simultaneous p and n type carrier injection in bilayer graphene channel by varying the longitudinal bias across the channel and the top gate voltage.
A K Sood, Anindya Das, Biswanath Chakraborty, Castro E V Novoselov K S Morozov S V Nilsson J Guinea F Geim A K Castro Neto A H, Gava P Lazzeri M Saitta A M Mauri F   +4 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Photon beam modeling: A comparative study of primo and gate simulation toolkits for the TrueBeam STx Linac [PDF]

Nuclear Technology and Radiation Protection
This study compares the PRIMO and GATE Monte Carlo simulation toolkits for modeling photon beams from a TrueBeam STx Linac used in radiation therapy.
Pham Hong Lam, Phan Tien Dung, Le Thi Hoang Anh, Pham Quang Trung   +3 more
doaj   +1 more source