Results 91 to 100 of about 6,242 (305)
Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
Perspectives on Medical EducationIntroduction: Power plays a crucial role in mentoring relationships as mentoring is inherently a social and relational practice. Power dynamics can function as a gatekeeper to students’ learning opportunities and experiences, making it crucial to build a
Hannelore van der Kloot +2 more
doaj +1 more source
Feminist Theory Reveals a Need for Justice over Autonomy in Research Ethics
Voices in Bioethics, 2018 Informed consent has remained one of the more debated topics within research ethics. Many scholars and bioethicists have wondered the best way to obtain it, who should give it, and if it is even necessary at all.
Alix E. Masters
doaj +1 more source
Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis
Advanced Science, EarlyView.In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley +1 more source
, 2018 Previous studies have firmly established the technological gatekeeper to be a key node in the innovation process - acquiring, translating, and disseminating external information throughout the R&D unit.
Whelan, Eoin +3 more
core
Advanced Science, EarlyView.High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott +5 more
wiley +1 more source
Dolmetschen im Polizeikontext - Dolmetscher/innen als Gatekeeper?
, 2019 Leitfadengestützte Experteninterviews mit sechs Polizeibeamten aus Wien und Oberösterreich geben Aufschluss über die Rolle von Polizeidolmetschern/Polizeidolmetscherinnen als Gatekeeper/innen.
Hackl, Susanne
core
Advanced Science, EarlyView.In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu +11 more
wiley +1 more source
Personalized Network‐Guided Neuromodulation Enhances Human Working Memory
Advanced Science, EarlyView.A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan +13 more
wiley +1 more source
The Research of Gatekeeper in WeChat Public Account--A Case Study of Xiamen [PDF]
, 2017 发轫于大众传播时代的“把关人”理论至今已走过70多个年头，从概念提出到不断的理论演进以及相关理论的中国化，尤其是经历上世纪90年代以来中国报业、电视、互联网的迅猛发展后，“把关人”已从学术理论变成传播常识与操作范式。 然而，大众传播时代丰富与发展而来的“把关人”理论，在微信公众号、新闻客户端等自体（WeMedia）迅猛崛起的短短数年内，因传播技术、传播模式与传媒生态的大改变而出现了短暂的困惑期。最显著的问题即是：“把关人”理论的有效性和可操作性在自媒体时代有何变化，当前层出不穷的虚假、不实信息是否跟 ...
刘亚楠
core