Results 41 to 50 of about 180,101 (334)

Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

open access: yesNature reviews: Gastroenterology & hepatology, 2018
Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels of the liver and are the most abundant non-parenchymal hepatic cell population.
S. Shetty, P. Lalor, D. Adams
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gatekeeping

open access: yesSSRN Electronic Journal, 2005
Collective choice bodies throughout the world use a diverse array of codified rules that determine who may exercise procedural rights,and in what order. This paper analyzes several two-stage decision-making models,focusing on one in which the first- moving actor has a unique, unilateral, procedural right to enforce the status quo, i.e., to exercise ...
Crombez, Christophe   +2 more
openaire   +2 more sources

Challenges of digital innovations : a set-top box based approach [PDF]

open access: yes, 2014
The chapter analyses the challenges of digital technology for television audience measurement systems. First, the current state of audience measurement in Belgium is described.
Berte, Katrien, Evens, Tom
core   +2 more sources

Solute carrier transporters: the metabolic gatekeepers of immune cells

open access: yesActa Pharmaceutica Sinica B, 2019
Solute carrier (SLC) transporters meditate many essential physiological functions, including nutrient uptake, ion influx/efflux, and waste disposal. In its protective role against tumors and infections, the mammalian immune system coordinates complex ...
Wenxin Song   +4 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Inside Lawyers: Friends or Gatekeepers? [PDF]

open access: yes, 2016
Part I of this Article sets the stage by contrasting two alternative proposals to reform the inside lawyer\u27s role—my reform and Hamermesh\u27s counterreform. Part II discusses the primary empirical disagreements between the two approaches.
Kim, Sung Hui
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Deconstructing the discourse of citizen journalism: Who says what and why it matters

open access: yesPacific Journalism Review, 2019
Since it emerged early this century, ‘citizen journalist’ and its related terms have been increasingly contested among groups including professional journalists, academics, and citizens themselves.
Elspeth Tilley, John Cokley
doaj   +1 more source

‘It all sounds very interesting, but we’re just too busy!’: exploring why ‘gatekeepers’ decline access to potential research participants with learning disabilities

open access: yes, 2020
A growing body of literature addresses why potential research participants decline to take part in research which could improve their and others’ lives.
P. Williams
semanticscholar   +1 more source

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