Results 141 to 150 of about 798,500 (344)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Quantum critical behavior of semisimple gauge theories [PDF]

open access: green, 2016
Jacob Kamuk Esbensen   +2 more
openalex   +1 more source

Super instanton counting and localization

open access: yes, 2019
We study the super instanton solution in the gauge theory with U$(n_{+}| n_{-})$ gauge group. Based on the ADHM construction generalized to the supergroup theory, we derive the instanton partition function from the super instanton moduli space through ...
Kimura, Taro, Pestun, Vasily
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Freezing and BPS jumping

open access: yesJournal of High Energy Physics
We report a novel BPS jumping phenomenon of 5d N $$ \mathcal{N} $$ = 1 supersymmetric gauge theories whose brane configuration is equipped with an O7-plane.
Sung-Soo Kim   +3 more
doaj   +1 more source

Nambu–Poisson gauge theory

open access: yesPhysics Letters B, 2014
We generalize noncommutative gauge theory using Nambu-Poisson structures to obtain a new type of gauge theory with higher brackets and gauge fields. The approach is based on covariant coordinates and higher versions of the Seiberg-Witten map. We construct a covariant Nambu-Poisson gauge theory action, give its first order expansion in the Nambu-Poisson
Jurčo, Branislav   +2 more
openaire   +3 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

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