Results 121 to 130 of about 5,576,143 (310)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Some Remarks on Rovelli's "Why Gauge?" [PDF]
, 2013 Rovelli's "Why Gauge?" offers a parable to show that gauge-dependent quantities have a modal and relational physical significance. We subject the morals of this parable to philosophical scrutiny and argue that, while his overarching point stands, there ...
Teh, Nicholas
core
Topology of 3-dimensional manifolds [PDF]
ریاضی و جامعهThis is the second paper from a trio which reviews some of the progress in low dimensional topology in the past century. Starting with the work of Poincare in the last years of 19th century and first few years of 20th century, we review the major steps ...
Eaman Eftekhary
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Gauge coupling unification in gauge-Higgs GUT: theory and phenomenology
Journal of High Energy PhysicsWe present a concise survey of the running of gauge couplings in realistic models of gauge-Higgs grand unification in a slice of AdS5 space and investigate their potential unification. Besides unifying the gauge groups of the Standard Model, these models
Andrei Angelescu +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Principal Bundles and Gauge Theories [PDF]
, 2011 This set of lecture notes fills a hole that in the authors opinion currently exists in the available literature on (prequantum or first quantised) gauge theory: theoretical physics texts do lots of calculations in coordinates and fail to appreciate the ...
Vákár, Matthijs
core
A Partially Fixed Background Field Gauge
Journal of High Energy PhysicsWe examine the incorporation of gauge symmetries in the modern effective field theory (EFT) matching paradigm with a particular focus on spontaneously broken symmetries.
Anders Eller Thomsen
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Gauge Theory and Supergravity Duality in the PP-Wave Background [PDF]
, 2005 We test the matrix theory conjecture in the pp-wave by studying two-body interactions between gravitons and membranes. We compute the one-loop effective potential of matrix theory and compare it to the light cone Lagrangian of linearized supergravity. We
Lee, Hok Kong
core +1 more source