Results 101 to 110 of about 788,627 (295)

A simplicial gauge theory

, 2011
We provide an action for gauge theories discretized on simplicial meshes, inspired by finite element methods. The action is discretely gauge invariant and we give a proof of consistency. A discrete Noether's theorem that can be applied to our setting, is
Bossavit A., Ciarlet P. G., Dodziuk J., Haugazeau Y., Kobayashi S., Mansfield E. L., Mansfield E. L., Prasolov V. V., Raviart P. A., Rothe H. J., Snorre H. Christiansen, Strang G., Tore G. Halvorsen, Weinberg S., Weinberg S., Yee K. S.   +15 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Exciting LLM geometries

Journal of High Energy Physics, 2018
We study excitations of LLM geometries. These geometries arise from the backreaction of a condensate of giant gravitons. Excitations of the condensed branes are open strings, which give rise to an emergent Yang-Mills theory at low energy.
Robert de Mello Koch, Jia-Hui Huang, Laila Tribelhorn   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Fluid/p-form duality

Physics Letters B
In this study, we demonstrate that an inviscid fluid in a near-equilibrium state, when viewed in the Lagrangian picture in d+1 spacetime dimensions, can be reformulated as a (d−1)-form gauge theory.
V. Taghiloo, M.H. Vahidinia
doaj   +1 more source

String Tensions and Three Dimensional Confining Gauge Theories

, 2002
In the context of gauge/gravity duality, we try to understand better the proposed duality between the fractional D2-brane supergravity solutions of (Nucl. Phys. B 606 (2001) 18, hep-th/0101096) and a confining 2+1 dimensional gauge theory.
A. Hanany, A. Kehagias, A. Loewy, B. Lucini, B.S. Acharya, C.G. Callan, C.G. Callan, C.P. Herzog, C.P. Herzog, Christopher P. Herzog, D. Morrison, E. Witten, G.W. Gibbons, I.R. Klebanov, I.R. Klebanov, I.R. Klebanov, I.R. Klebanov, J. Ambjorn, J. Ambjorn, J. Ambjorn, J. Maldacena, J.D. Edelstein, J.M. Maldacena, L. Del Debbio, M. Cvetič, M.J. Strassler, M.R. Douglas, R. Myers, S.S. Gubser   +28 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Cold atoms meet lattice gauge theory. [PDF]

Philos Trans A Math Phys Eng Sci, 2022
Aidelsburger M, Barbiero L, Bermudez A, Chanda T, Dauphin A, González-Cuadra D, Grzybowski PR, Hands S, Jendrzejewski F, Jünemann J, Juzeliūnas G, Kasper V, Piga A, Ran SJ, Rizzi M, Sierra G, Tagliacozzo L, Tirrito E, Zache TV, Zakrzewski J, Zohar E, Lewenstein M.   +21 more
europepmc   +1 more source