Results 31 to 40 of about 113,768 (314)

Cross-cultural correlates of homophobia: comparison of Italian and Spanish attitudes towards homosexuals

open access: yesMediterranean Journal of Clinical Psychology, 2021
Background: Homophobia or the reaction against homosexuals could be based on the structural ideology of the society, on its institutions or on power relationships, which can incite contempt, sometimes even to deadly violence, regarding those not ...
Enrico Perilli   +7 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Luang Prabang, sanctuaire Unesco et paradis gay

open access: yesGenre, Sexualité et Société, 2011
Luang Prabang is a town in Northern Laos that has been on the World Heritage List since 1995. Famous for its Buddhist monasteries and orange-robed monks, as well as for its colonial architecture, its international reputation has grown quickly. It has now
David Berliner
doaj   +1 more source

Pathways to fatherhood: evaluating the priorities of self-identified gay and bisexual men pursuing family building options

open access: yesF&S Reports, 2022
Objective: To assess the priorities and decisions of gay and bisexual men pursuing fatherhood. Design: Cross-sectional study. Setting: Internet-based survey.
Brent M. Hanson, M.D.   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Les « faux » mariages homosexuels de Sidi Ali au Maroc : enjeux d’un scandale médiatique

open access: yesRevue des Mondes Musulmans et de la Méditerranée, 2011
The cases of "gay marriages" in Ksar el Kebir and then in Sidi Ali have caused an uproar in the Moroccan press. Beyond the emotions raised by the 'outrageous' mix between the respected institution of marriage and an illegal form of sexuality, this affair
Florence Bergeaud-Blackler, Victor Eck
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Mental Health Professionals and Lesbian, Gay, Bisexual, Transgender, and Queer: Current Scenario

open access: yesJournal of Psychiatry Spectrum, 2022
Nearly 5% of population identify themselves as lesbian, gay, bisexual, transgender, and queer (LGBTQ). It is important to know what constitutes this subset of the population and also know what constitutes human sexuality.
Chidatma Narayana Arampady   +4 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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