Results 31 to 40 of about 197,248 (298)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Design and validation of a selective binding 3D printer for bio-based construction materials
Developments in the Built EnvironmentWe aim to address that home-made design and assembly can be effective to investigate several sizes and natures of construction materials. This study offers a new design that accepts different powder and bio-based materials to enhance the functionality of
Valentine Danché +5 more
doaj +1 more source
, 1995 Monthly newsletter of the Gay and Lesbian Garden Club discussing November and December events in 1995 as well as plans for ...
Gay and Lesbian Garden Club
core +7 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Luang Prabang, sanctuaire Unesco et paradis gay
Genre, Sexualité et Société, 2011 Luang Prabang is a town in Northern Laos that has been on the World Heritage List since 1995. Famous for its Buddhist monasteries and orange-robed monks, as well as for its colonial architecture, its international reputation has grown quickly. It has now
David Berliner
doaj +1 more source
F&S Reports, 2022 Objective: To assess the priorities and decisions of gay and bisexual men pursuing fatherhood. Design: Cross-sectional study. Setting: Internet-based survey.
Brent M. Hanson, M.D. +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Les « faux » mariages homosexuels de Sidi Ali au Maroc : enjeux d’un scandale médiatique
Revue des Mondes Musulmans et de la Méditerranée, 2011 The cases of "gay marriages" in Ksar el Kebir and then in Sidi Ali have caused an uproar in the Moroccan press. Beyond the emotions raised by the 'outrageous' mix between the respected institution of marriage and an illegal form of sexuality, this affair
Florence Bergeaud-Blackler, Victor Eck
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Mental Health Professionals and Lesbian, Gay, Bisexual, Transgender, and Queer: Current Scenario
Journal of Psychiatry Spectrum, 2022 Nearly 5% of population identify themselves as lesbian, gay, bisexual, transgender, and queer (LGBTQ). It is important to know what constitutes this subset of the population and also know what constitutes human sexuality.
Chidatma Narayana Arampady +4 more
doaj +1 more source