Results 31 to 40 of about 13,201 (305)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Fargo-Moorhead PFLAG (Parents, Families and Friends of Lesbians and Gays) Records, 1988-2004. [PDF]
, 2018 The Fargo-Moorhead PFLAG (Parents, Families and Friends of Lesbians and Gays) was established in September 1986. A Statement of Purpose gives ?Our group of Parents and Friends of Lesbians and Gays (Parents-Flag, or P-Flag) is part of a large network of ...
Fargo-Moorhead PFLAG (Parents, Families and Friends of Lesbians and Gays)
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Death Threat sent of Campus Mail to those supporting Non-Discrimination Policy [2] [PDF]
, 1990 Text document typed letter sent to Deb Burrington stating that AIDS is a curse to the Homosexuals for their behavior and they should suffer for itConverted from .jpg to .pdf for ...
William Crowder, Utah Students Against Gays
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Morphological Analysis of Gay's Spoken Discourse
JPAIR, 2011 The language of gays known as Gay speaks has now earned respect from the community and observably been infused in the mainstream language of the society.
Ariel B. Lunzaga +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Oral History Interview with Josie Carter and Jaime Gays, May 6, 2011 [PDF]
, 2011 Josie Carter and Jaime Gays are drag performers and long-time friends. They discuss the "gay scene" in Milwaukee in the 1950s and 1960s, mentioning specific bars such as Castaways, the White Horse, the Mint, and others; drag pageants throughout the ...
Carter, Josie and Jaime Gays
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De Sur a Norte: Chilangos gays en Toronto [PDF]
, 2017 "De Sur a Norte. Chilangos gays en Toronto es el tercer libro de Rodrigo Laguarda, y cuyo eje temático –al igual que los dos anteriores- giran en torno a lo que él denomina “homosexualidades masculinas”.
JUAN MIGUEL SARRICOLEA TORRES
core +1 more source
Discutindo homofobia nas organizações e no trabalho
Revista Espaço Acadêmico, 2014 O presente artigo busca discutir a homofobia e suas variadas manifestações no ambiente organizacional. Essa temática é relevante socialmente e tem se tornado mais frequente nos estudos em administração.
Henrique Luiz Caproni Neto +1 more
doaj