Results 101 to 110 of about 15,101 (190)

Sinbaglustat ameliorates disease pathology in a murine model of GM1 gangliosidosis without affecting CNS ganglioside levels

Neurobiology of Disease
Sinbaglustat is a brain-penetrating small molecule that inhibits the non-lysosomal glucocerebrosidase (GBA2) and, with lower potency, glucosylceramide synthase (GCS). Sinbaglustat has passed clinical phase I.
Rouven Wannemacher, Lorna Jubran-Rudolf, Isabel Zdora, Eva Leitzen, Karl Rohn, Virginie Sippel, Christoph Paschen, Peter Blattmann, Wolfgang Baumgärtner, Ingo Gerhauser, Michel Alexander Steiner   +10 more
doaj   +1 more source

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease [PDF]

, 2017
Galactosylceramidase (GALC) is the lysosomal β-galactosidase responsible for the hydrolysis of galactosylceramide. Inherited deficiency in GALC causes Krabbe disease, a devastating neurological disorder characterized by accumulation of galactosylceramide
Aerts, Johannes M F G, Biela-Banas, Anna, Boot, Rolf G., Cachón‐González, M. Begoña, Cox, Timothy M., Florea, Bogdan I., Herrera Moro, Daniela, Kallemeijn, Wouter W., Kim, Nee Na, Marques, André R. A., Martin, Olivier R., Nelson, Jessica K., Ottenhoff, Roelof, Overkleeft, Herman S., Scheij, Saskia, van Roomen, Cindy P.A.A., Verhoek, Marri, Willems, Lianne I.   +17 more
core   +1 more source

Symplectic Tate homology [PDF]

, 2015
For a Liouville domain $W$ satisfying $c_1(W)=0$, we propose in this note two versions of symplectic Tate homology $\underrightarrow{H}\underleftarrow{T}(W)$ and $\underleftarrow{H}\underrightarrow{T}(W)$ which are related by a canonical map $\kappa ...
Albers, Peter, Cieliebak, Kai, Frauenfelder, Urs   +2 more
core   +2 more sources

Weak effects in b-jet production at hadron colliders

, 2009
One of the main challenges of the Tevatron at Fermilab and the Large Hadron Collider (LHC) at CERN is the determination of Standard Model (SM) parameters at the TeV scale.
Kuhn, J. H., Scharf, A., Uwer, P.
core   +1 more source

Variations in rumen microbiota and host genome impacted feed efficiency in goat breeds

Frontiers in Microbiology
IntroductionImproving feed efficiency (FE) is a significant goal in animal breeding programs. Variations in FE and its relationship with rumen microbiota remain poorly understood across different goat breeds.MethodsThis study assessed the influence of ...
Alaa Emara Rabee, Ibrahim Abou-souliman, Ahmed I. Yousif, Mebarek Lamara, Mohamed A. El-Sherbieny, Eman Ali Elwakeel, Ahmed M. Sallam   +6 more
doaj   +1 more source

A Computationally Efficient Discrete Bit-Loading Algorithm for OFDM Systems Subject to Spectral-Compatibility Limits

, 2015
International audienceThis paper considers bit-loading algorithms to maximize throughput under total power and spectral mask constraints in interference-free OFDM systems. The contribution is twofold.
Amis Cavalec, Karine, Chonavel, Thierry, Siohan, Pierre, VO, Thanh Nhân   +3 more
core   +3 more sources

Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation

Frontiers in Immunology
Background and purposePromoting adaptive immunity with ICIs has drastically improved melanoma prognosis, but not for all patients. Some cases relapse in the first few months, while others keep durable benefit, even after immunotherapy discontinuation. To
Eleni Palli, Matthieu Lavigne, Panagiotis Verginis, Themis Alissafi, Amalia Anastasopoulou, Georgios Lyrarakis, John M. Kirkwood, Helen Gogas, Dimitrios C. Ziogas   +8 more
doaj   +1 more source

Les ouvriers du désir. Du produit au consommateur, la médiation publicitaire

, 1997
D'où les objets tirent-ils leur pouvoir ? Qu'est-ce qui nous les fait désirer ? Il n'est guère de question plus fondamentale. Elle réunit autour d'elle les interrogations les plus tenaces de la métaphysique et de la religion comme les discours les plus ...
Hennion, Antoine, Méadel, Cécile
core   +1 more source

The role of GBA2 in controlling locomotor activity [PDF]

Glycosphingolipids are major constituents of cellular membranes, fulfilling both structural and functional roles. Modifications of the basic glycosphingolipid glucosylceramide (GlcCer) result in numerous complex glycosylated and sialylated ...
Woeste, Marina Amelie
core  

Cytoskeletal defects in GBA2 knockout-testis already occur during the first spermatogenic wave.

, 2015
Raju Diana, Sophie Schonauer, Hussein Hamzeh, Czaplinski Kevin, Frank Bradke, vom Dorp Katharina, D. Weinberg Peter, Yildiz Yildiz, Trötschel Christian, Poetsch Ansgar, Bernadette Breiden, Sandhoff Konrad, Heinz Gisslinger, Dagmar Wachten   +13 more
openalex   +2 more sources