Results 51 to 60 of about 1,568 (176)

The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells.

PLoS ONE, 2013
Dysfunctional zinc signaling is implicated in disease processes including cardiovascular disease, Alzheimer's disease and diabetes. Of the twenty-four mammalian zinc transporters, ZIP7 has been identified as an important mediator of the 'zinc wave' and ...
Stephen A Myers, Alex Nield, Guat-Siew Chew, Mark A Myers   +3 more
doaj   +1 more source

Integrative Advances in Equine Genomics From Reference Assemblies to Evolutionary History and Key Traits

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT Horses are major domestic animals and cultural symbols that have accompanied humans for millennia. They underpin transport, agriculture, warfare and sport, and also provide a model for studying domestication, complex traits and adaptive evolution.
Ying Lu, Ruoshan Ma, Bo Wang, Jiao Wu, Yuqing Chong, Zhendong Gao, Weidong Deng   +6 more
wiley   +1 more source

Metabolic Reprogramming Analysis of Wheat Response to Low Temperature Stress Under Nitrogen Supply

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
Low temperature stress triggers a defense network that maintains growth at the expense of inhibiting photosynthesis and chlorophyll synthesis. Temperature recovery effectively repairs low temperature‐induced damage and enhances stress resistance, while nitrogen supply can further augment these protective processes to strengthen cold tolerance ...
Qiujuan Jiao, Haitao Liu, Zhijie Ren, Gezi Li, Lina Fan, Jiayu Hu, Yufang Huang, Shiliang Liu, Youliang Ye, Yanan Zhao   +9 more
wiley   +1 more source

Association of the Congenital Neuromuscular Form of Glycogen Storage Disease Type IV With a Large Deletion and Recurrent Frameshift Mutation

, 2014
Anderson disease, also known as glycogen storage disease type IV (MIM 232500), is a rare autosomal recessive disorder caused by a deficiency of glycogen branching enzyme.
Li, Sing-Chung;Hwu, Wuh-Liang;Lin, Ju-Li;Bali, Deeksha S.;Yang, Chen;Chu, Shih-Ming;Chien, Yin-Hsiu;Chou, Hung-Chieh;Chen, Chien-Yi;Hsieh, Wu-Shiun;Tsao, Po-Nien;Chen, Yuan-Tsong;Lee, Ni-Chung, 胡務亮 ;謝武勳 ;李妮鍾 ;簡穎秀   +1 more
core   +2 more sources

Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. [PDF]

PLoS ONE, 2010
When oxygen becomes limiting, cells reduce mitochondrial respiration and increase ATP production through anaerobic fermentation of glucose. The Hypoxia Inducible Factors (HIFs) play a key role in this metabolic shift by regulating the transcription of ...
Nuria Pescador, Diego Villar, Daniel Cifuentes, Mar Garcia-Rocha, Amaya Ortiz-Barahona, Silvia Vazquez, Angel Ordoñez, Yolanda Cuevas, David Saez-Morales, Maria Laura Garcia-Bermejo, Manuel O Landazuri, Joan Guinovart, Luis del Peso   +12 more
doaj   +1 more source

A novel approach to characterize phenotypic variation in GSD IV: Reconceptualizing the clinical continuum

Frontiers in Genetics, 2022
Purpose: Glycogen storage disease type IV (GSD IV) has historically been divided into discrete hepatic (classic hepatic, non-progressive hepatic) and neuromuscular (perinatal-congenital neuromuscular, juvenile neuromuscular) subtypes. However, the extent
Bridget T. Kiely, Rebecca L. Koch, Leticia Flores, Danielle Burner, Samantha Kaplan, Priya S. Kishnani   +5 more
doaj   +1 more source

Interplay of RNA m6A/m1A/m5C/m7G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
In this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Shiyin Chen, Jiawei Mao, Lin Xu, Linbei Lu, Yajuan Hao   +4 more
wiley   +1 more source

Gene dosage, expression, and ontology analysis identifies driver genes in the carcinogenesis and chemoradioresistance of cervical cancer. [PDF]

PLoS Genetics, 2009
Integrative analysis of gene dosage, expression, and ontology (GO) data was performed to discover driver genes in the carcinogenesis and chemoradioresistance of cervical cancers.
Malin Lando, Marit Holden, Linn C Bergersen, Debbie H Svendsrud, Trond Stokke, Kolbein Sundfør, Ingrid K Glad, Gunnar B Kristensen, Heidi Lyng   +8 more
doaj   +1 more source

Skeletal-Muscle-Specific Overexpression of Chrono Leads to Disruption of Glucose Metabolism and Exercise Capacity

Life, 2022
Disruption of circadian rhythms is related to disorders of glucose metabolism, and the molecular clock also exists in skeletal muscle. The ChIP-derived repressor of network oscillator (Chrono) and brain and muscle ARNT-like 1 (Bmal1) are core circadian ...
Shiyi He, Lu Yan, Rongxin Zhu, Hao Wei, Jianxiong Wang, Lan Zheng, Ying Zhang   +6 more
doaj   +1 more source

An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic

Journal of Animal Breeding and Genetics, Volume 143, Issue 1, Page 35-49, January 2026.
ABSTRACT Meiotic recombination is an essential process for shuffling genetic diversity in sexually reproducing organisms, can vary within and between individuals in response to intrinsic and extrinsic factors, and can be heritable. Interestingly, recombination rate has been found to vary with age in some species, but to date, there have been no ...
Evelyn Jade, Mathew D. Littlejohn, Katie Eketone, Richard J. Spelman, Jessica Stapley, Anna W. Santure   +5 more
wiley   +1 more source