Results 61 to 70 of about 1,590 (147)
Interplay of RNA m6A/m1A/m5C/m7G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer
FASEB BioAdvances, Volume 8, Issue 5, May 2026.In this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Shiyin Chen +4 more
wiley +1 more source
An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic
Journal of Animal Breeding and Genetics, Volume 143, Issue 1, Page 35-49, January 2026.ABSTRACT Meiotic recombination is an essential process for shuffling genetic diversity in sexually reproducing organisms, can vary within and between individuals in response to intrinsic and extrinsic factors, and can be heritable. Interestingly, recombination rate has been found to vary with age in some species, but to date, there have been no ...
Evelyn Jade +5 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 12, Page 3706-3728, December 2025.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Genome-Environmental Risk Assessment of Cocaine Dependence
Frontiers in Genetics, 2012 Cocaine-associated biomedical and psychosocial problems are substantial 21st century global burdens of disease. This burden is largely driven by a cocaine dependence process that becomes engaged with increasing occasions of cocaine product use.
Changshuai eWei +2 more
doaj +1 more source
Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies
Annals of Neurology, Volume 98, Issue 3, Page 448-470, September 2025.[Color figure can be viewed at www.annalsofneurology.org] Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical ...
Brent L. Fogel +10 more
wiley +1 more source
Veterinary and Comparative Oncology, Volume 23, Issue 3, Page 346-357, September 2025.ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is one of the most prevalent haematological malignancies in both humans and dogs, characterised in both species by significant clinical heterogeneity and limited prognostic predictability. With the introduction of next‐generation sequencing (NGS) technologies in veterinary medicine over the past decade ...
Antonella Fanelli +4 more
wiley +1 more source
Advanced Healthcare Materials, Volume 14, Issue 21, August 19, 2025.This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua +9 more
wiley +1 more source
Glycogen storage disease type IV : A rare cause for neuromuscular disorders or often missed? [PDF]
, 2018 Advancements in genetic testing now allow early identification of previously unresolved neuromuscular phenotypes. To illustrate this, we here present diagnoses of glycogen storage disease IV (GSD IV) in two patients with hypotonia and delayed development
Dooijes, Dennis +17 more
core +1 more source
Physiological Reports, Volume 13, Issue 12, June 2025.Abstract Compared with 2D monolayers, 3D models more closely mimic native muscle tissue and allow functional measurements. A more complete understanding of how culture conditions and duration affect myotube maturity/function is crucial for validating the transition to 3D systems.
Benjamin R. Tollitt +5 more
wiley +1 more source
Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.Antisense oligonucleotide (ASO) treatment in a mouse model of Pompe disease achieves robust knockdown of glycogen synthase (GYS1). ASO treatment reduces glycogen content in skeletal muscle. Combination of ASO and enzyme replacement therapy (ERT) further improves motor performance compared to ASO alone in a mouse model of Pompe disease.
Lan Weiss +18 more
wiley +1 more source