Results 221 to 230 of about 208,701 (315)

The Recycling Endosomal (Na+, K+)/H+ Exchanger NHE6/SLC9A6 Facilitates Signal Transduction by Shuttling Cyclin‐Dependent Kinase 5 to the Plasma Membrane

open access: yesActa Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The alkali cation/proton exchanger NHE6/SLC9A6 regulates luminal pH homeostasis and trafficking of recycling endosomes in most tissues, especially neurons. Loss‐of‐function mutations in NHE6 cause Christianson Syndrome, an X‐linked neurodevelopmental and neurodegenerative disorder; however, the underlying molecular and cellular mechanisms ...
Rebecca Flessner   +6 more
wiley   +1 more source

Periodontitis in Patients With Severe Obesity: From the Oral and Gut Microbiota Dysregulation to the Visceral Adipose Tissue Inflammatory and Metabolic Disorders

open access: yesThe FASEB Journal, Volume 40, Issue 9, 15 May 2026.
In patients with severe obesity, periodontitis is associated with oral microbiota dysbiosis which influences gut microbiota composition by increasing Proteobacteria proportion. These alterations are linked to systemic immune and metabolic changes, including higher circulating levels of anti‐Porphyromonas gingivalis lgG and deregulated lipid profile ...
Katy Thouvenot   +11 more
wiley   +1 more source

DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study

open access: yesAnnals of Neurology, Volume 99, Issue 5, Page 1210-1223, May 2026.
Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito   +10 more
wiley   +1 more source

Integrating image‐based phenotyping and marker‐assisted selection to optimize the selection of potato clones for chipping and resistance to viruses X and Y

open access: yesCrop Science, Volume 66, Issue 3, May/June 2026.
Abstract Potato (Solanum tuberosum L.) is the most important non‐cereal crop for global food security. To meet the demands of the processing, potato clones with good frying quality and industrial yield and resistance to major viral diseases are required. This study aimed to integrate image‐based phenotyping and marker‐assisted selection to optimize the
Leticia Novais Padua   +14 more
wiley   +1 more source

Optimization of wheat breeding programs using an evolutionary algorithm achieves enhanced genetic gain through strategic resource allocation

open access: yesCrop Science, Volume 66, Issue 3, May/June 2026.
Abstract Plant breeding is a complex process that involves trade‐offs among competing breeding objectives and limited resources. Despite the necessity for optimization of breeding program design, its inherent complexity can make this challenging.
Azadeh Hassanpour   +3 more
wiley   +1 more source

Methylprednisolone pulses are associated with faster remission in Giant Cell Arteritis: a multicentre inception cohort study. [PDF]

open access: yesArthritis Res Ther
Fernández-Guitián R   +19 more
europepmc   +1 more source

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