Results 81 to 90 of about 208,701 (315)

New insights into the pathogenesis of giant cell arteritis [PDF]

open access: yes, 2016
Giant cell arteritis (GCA) is an inflammatory chronic disease occurring exclusively in elderly individuals. Until recently, the disease has been considered a unique disease resulting from the interaction in the walls of susceptible arteries, between an ...
Francesco Ciccia   +110 more
core   +3 more sources

Stable Neural Signal Recording Processed by Memristor‐Based Reservoir Computing System

open access: yesAdvanced Intelligent Systems, EarlyView.
This work introduces a memristor‐based reservoir computing (RC) system for real‐time, energy‐efficient processing of neural signals in brain‐machine interface (BMI). Combined with flexible mesh neural probes with tissue‐like flexibility and subcellular‐scale features that enable consistent, long‐term tracking of single‐cell neural activities, the ...
Soohyeon Kim   +10 more
wiley   +1 more source

Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation [PDF]

open access: yes, 2019
Human ileal bile acid-binding protein (hI-BABP) has a key role in the intracellular transport of bile salts. To explore the role of histidine protonation in the binding process, the pH-dependence of bile salt binding and internal dynamics in hI-BABP was ...
Egyed, Orsolya   +6 more
core   +4 more sources

Over‐the‐Top Anterior Cruciate Ligament Reconstruction With Lateral Extra‐articular Tenodesis in Pediatric Athletes Provides Excellent Functional Outcomes and Preserves Growth Plate Symmetry

open access: yesArthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To assess clinical and radiological outcomes of pediatric anterior cruciate ligament (ACL) reconstruction using the over‐the‐top technique (OTT) combined with the lateral extra‐articular tenodesis (LET) technique in skeletally immature patients, providing insights into its safety, efficacy, and effects on the growing knee.
Abel Gomez‐Caceres   +6 more
wiley   +1 more source

What is the absolute risk of developing diabetes mellitus in patients with glucocorticoid-treated polymyalgia rheumatica and giant cell arteritis? a systematic review and meta-analysis [PDF]

open access: yes, 2017
Background: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are treated with glucocorticoids (GCs) but long-term GC use is associated with diabetes mellitus (DM).
Harris, Emma   +3 more
core   +1 more source

Prescribing of Medication to Prevent Glucocorticoid Harms in Patients With Polymyalgia Rheumatica: A Cross‐Sectional Study and Two Emulated Target Trials in the Clinical Practice Research Datalink Aurum

open access: yesArthritis &Rheumatology, EarlyView.
Objective Polymyalgia rheumatica (PMR) is a common indication for long‐term glucocorticoid (GC) treatment. Bone‐protective and gastroprotective medications are recommended for those at high risk of adverse events from GCs, but no trials have evaluated their effectiveness in PMR.
Helen Twohig   +5 more
wiley   +1 more source

Generalized Geometric Cluster Algorithm for Fluid Simulation

open access: yes, 2005
We present a detailed description of the generalized geometric cluster algorithm for the efficient simulation of continuum fluids. The connection with well-known cluster algorithms for lattice spin models is discussed, and an explicit full cluster ...
C. Day   +10 more
core   +1 more source

Higher complement C4 gene copy number constitutes a shared genetic risk factor for giant cell arteritis and IgA vasculitis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez   +296 more
wiley   +1 more source

Reappraisal of large artery involvement in giant cell arteritis: a population-based cohort over 70 years

open access: yesRMD Open
Objective To evaluate the incidence and outcomes of large artery (LA) involvement among patients with giant cell arteritis (GCA) and to compare LA involvement to non-GCA patients.Methods The study included Olmsted County, Minnesota, USA residents with ...
Kenneth J Warrington   +7 more
doaj   +1 more source

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