Results 1 to 10 of about 2,223 (141)

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation [PDF]

Advanced Science
The role of amino acid metabolism dysregulation in the development of type 2 diabetes remains elusive. Here, significant associations of human CREBBP/EP300 gene polymorphisms with circulating amino acid and glucose levels are reported. Through integrated
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
doaj   +3 more sources

A Genetically Encoded Biosensor for Characterizing Transport and Metabolism of Glutarate [PDF]

Advanced Science
Glutarate is a platform chemical with diversified applications. It is also an endogenous metabolite involved in various physiological processes. Deficiency in glutaryl‐CoA dehydrogenase (GcdH) for glutarate catabolism induces the inherited metabolic ...
Kaiyu Gao, Hui Zhang, Yidong Liu, Xianzhi Xu, Wei Liu, Zhaoqi Kang, Rong Xu, Shuang Hou, Ping Han, Chuanjuan Lü, Cuiqing Ma, Ping Xu, Chao Gao   +12 more
doaj   +3 more sources

Mendelian Randomization Analysis of Mitochondria‐Related Genes and Screening of Prognostic Genes in Colorectal Cancer [PDF]

Cancer Medicine
Background Mitochondria have been linked with inflammatory colorectal cancer (CRC) development; however, the association between mitochondria‐related genes (MRGs) and CRC remains unknown.
Limin Zhu, Xiaowei Huang, Fan Zhang, Jinzu Yang, Zhenye Xu   +4 more
doaj   +3 more sources

GCDH Acetylation Orchestrates DNA Damage Response and Autophagy via Mitochondrial ROS to Suppress Hepatocellular Carcinoma Progression [PDF]

Research
Metabolic enzyme dysregulation promotes hepatocellular carcinoma (HCC) progression through metabolic reprogramming and lysine acetylation. Glutaryl-CoA dehydrogenase (GCDH), a key enzyme in lysine metabolism, has been demonstrated to play an essential ...
Wei Tian, Yue Yang, Lili Meng, Chao Ge, Yuqi Liu, Canxue Zhang, Zhihong Huang, Chi Zhang, Hua Tian   +8 more
doaj   +2 more sources

Crotonylation and the Risk of Head and Neck Cancer: Insights from a Two-Sample Mendelian Randomization Study [PDF]

International Dental Journal
Background: Head and neck cancer (HNC) remains a major global health burden with limited improvement in survival. Crotonylation has been implicated in tumour biology, but its causal contribution to HNC risk is unclear.
Danya Zhang, Xinjian Zhang, Huiying Li, Anqi Liang, Yelei Liang, Zhiping Wang, Shanwei Shi, Yang Ge, Wenfeng Gao, Xinpeng Liu   +9 more
doaj   +2 more sources

Crotonylation-related gene GCDH promotes osteoarthritis pathogenesis through flavin adenine dinucleotide signaling: mechanism exploration and experimental validation [PDF]

Frontiers in Nutrition
IntroductionOsteoarthritis (OA) is a prevalent degenerative joint disorder characterized by progressive cartilage degradation and synovial inflammation.
Jingkai Di, Jingkai Di, Zijian Guo, Yijing Di, Luyi Zhang, Yingda Qin, Feida Wang, Chuan Xiang   +7 more
doaj   +2 more sources

Glutaryl-CoA dehydrogenase (GCDH) enhances renal malignancy risk via modulating glutarylcarnitine levels [PDF]

Discover Oncology
Background Crotonylation, a recently identified lysine acylation, plays a critical role in post-translational modifications [1]. It has been implicated in tumorigenesis by modulating metabolic reprogramming [2], DNA repair, immune evasion [3], and ...
Xuanshuo Liu, Bohua Chen, Jianghao Yuan, Shuhao Li, Lei Gao, Mingyan Chu, Shicang Fan, Weiwei Fan   +7 more
doaj   +2 more sources

Mendelian Randomization and Bioinformatics Analysis Reveal the Potential Protective Role of Metformin in Primary Liver Cancer. [PDF]

Food Sci Nutr
Using two‐sample Mendelian randomization and bioinformatics, this study found metformin associated with reduced primary liver cancer (PLC) risk (p = 0.026), without links to HCC/ICC. Key genes (e.g., DDX52, KIF11) and pathways (cGMP‐PKG signaling, fatty acid metabolism) were identified.
Ma Y, Qi J, Chen Z, Zhang Y, Liu K, Suo J, Chen B, Bu Y.   +7 more
europepmc   +2 more sources

Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer [PDF]

eLife
The regulation of gene expression is an integral cellular process orchestrated by epigenetic marks like histone modifications. Perturbations in the activity or abundance of epigenetic factors can lead to tumorigenesis.
Deepak Pant, Parik Kakani, Rushikesh Joshi, Abin Sabu, Shruti Agrawal, Atul Samaiya, Sanjeev Shukla   +6 more
doaj   +2 more sources

Biochemical Testing Promotes Interpretation of Variants of Uncertain Significance in Prenatal Genetic Disease Testing in Four Organic Acidurias. [PDF]

Clin Genet
This review demonstrates how amniotic fluid biochemical testing provides critical phenotypic evidence (ACMG PP4) for reclassifying variants of uncertain significance (VUS) in prenatal organic acidurias. Integrating metabolite analysis with genetic testing enhances diagnostic accuracy and enables informed clinical decisions for affected families ...
Yin K, Qi Q.
europepmc   +2 more sources