Results 61 to 70 of about 2,273 (178)

Cosmological expansion on a dilatonic brane-world [PDF]

, 2001
In this paper we study brane-world scenarios with a bulk scalar field, using a covariant formalism to obtain a 4D Einstein equation via projection onto the brane.
Akama K, Andrew Mennim, Barceló C, Bean R, Bowcock P, Chamblin A, Chamblin A, Chung D, Csáki C, Darmois G, Ellwanger U, Faraoni V, Flannagan E E, Gogberashvili M, Gogberashvili M, Grindstein B, Gubser S, Israel W, Israel W, Kolb E W, Kraus P, Lanczos K, Lanczos K, Maeda K, Misner C W, Mukohyama S, Mukohyama S, Richard A Battye, Salopek D S, Sen N, Vollick D, Wald R M, Will C M   +32 more
core   +2 more sources

Rescue of Glutaric Aciduria Type I in Mice by Liver-Directed Therapies [PDF]

, 2023
Glutaric aciduria type I (GA-1) is an inborn error of metabolism with a severe neurological phenotype caused by the deficiency of glutaryl-coenzyme A dehydrogenase (GCDH), the last enzyme of lysine catabolism.
Asokan, Aravind, Barzi, Mercedes, Beasley, James, Bissig, Karl-Dimiter, Bissig-Choisat, Beatrice, Chen, Tong, Diehl, Anna Mae, El-Gharbawy, Areeg, Everitt, Jeffrey I, Gonzalez, Trevor J, Hemmingsen, Madeline, Johnson, Collin G, Lagor, William R, Ma, Yunhan, Maeso-Diaz, Raquel, Peck, Cheryl K, Rodriguiz, Ramona M, Rosales, Alan, Stiles, Ashlee R, Wetsel, William C, Wood, Timothy C, Young, Sarah P   +21 more
core   +2 more sources

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Glutarate regulates T cell metabolism and anti-tumour immunity [PDF]

, 2023
T cell function and fate can be influenced by several metabolites: in some cases, acting through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through post-translational modification of lysines in important targets.
Antrobus, Robin, Barbieri, Laura, Bargiela, David, Cunha, Pedro P., Foskolou, Iosifina P., Grice, Guinevere L., Hughes, Rob, Johnson, Randall S., Koivunen, Peppi, Minogue, Eleanor, Nathan, James A., Quaranta, Alessandro, Sah-Teli, Shiv K., Velica, Pedro, Wadsworth, Brennan J., Wheelock, Craig E., Zurita, Javier   +16 more
core   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Genetic basis of hyperlysinemia [PDF]

, 2013
Background: Hyperlysinemia is an autosomal recessive inborn error of L-lysine degradation. To date only one causal mutation in the AASS gene encoding aminoadipic semialdehyde synthase has been reported.
Augoustides-Savvopoulou, P. (Persa), Baumgartner, M.R. (Matthias), Coşkun, T. (Turgay), Denis, S. (Simone), Duran, M. (Marinus), Houten, S.M. (Sander M.), Häberle, J. (Johannes), Klerk, J.B.C. (Johannes) de, Knegt, A.C. (Alida), Poll-The, B.T., Ruiter, J.P.N. (Jos), Sass, J.O. (Jörn Oliver), Te Brinke, H. (Heleen), Wanders, R.J.A. (Ronald), Zschocke, J. (Johannes)   +14 more
core   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Analysis of polymorphic marker rs9384 located in the GCDH gene region associated with glutaricaciduria type 1. [PDF]

, 2016
زمینه و هدف: گلوتاریک اسید یوریای نوع 1 نوعی اختلال متابولیکی عصبی می باشد که در اثر جهش در ژن رمز کننده آنزیم گلوتاریل کوآدهیدروژناز (GCDH) ایجاد می شود.
Badr, Zahra., Jazayeri, Ali., Salehi, Zivar., Vallian-Brojeni, Sadegh.   +3 more
core  

Increased susceptibility to quinolinic acid-induced seizures and long-term changes in brain oscillations in an animal model of glutaric acidemia type I [PDF]

, 2022
Glutaric acidemia type I (GA-I) is an inborn error of metabolism of lysine, hydroxylysine, and tryptophan, caused by glutaryl-CoA-dehydrogenase (GCDH) deficiency, characterized by the buildup of toxic organic acids predominantly in the brain. After acute
Calcagnotto, Maria Elisa, Caus, Letícia Barbieri, Pasquetti, Mayara Vendramin, Seminotti, Bianca, Wajner, Moacir, Woontner, Michael   +5 more
core  

Glutaric aciduria type 1 in children. Clinical presentation of 46 cases in Russian families

Нервно-мышечные болезни, 2021
Background. Glutaric aciduria type 1 is an autosomal recessive disease caused by mutations in the GCDH gene, which encodes the enzyme glutaryl‑CoA dehydrogenase.
S. V. Mikhailova, E. V. Saifullina, P. V. Baranova, V. P.   Vorontsova, D.  I.   Gribov, M.   V. Zhivihina, A. N.   Slatetskaya, R.  V.   Magzhanov, V. A.  Samokhvalov, M.  N.  Virtseva, L.     P. Borscheva, E.  E.  Koh, M.   V.  Novikova, A. V.   Abrukova, E.     Yu. Belyashova, N.    Yu. Gerasimenko, L.     V. Guseva, Zh.     V. Yukhimenko, N.     V. Nikitina, T.  I.   Belyaeva, T.   A.  Shkurko, N.   A.  Pichkur, V.     S. Kakaulina, N.   L. Pechatnikova, N .  A. Polyakova, S.    A. Korostelev, D.    V. Pyankov, I.   V. Kanivets, N.   A.  Demina, E.     Yu. Pyrkova, G.     V. Baidakova, M.    V. Kurkina, E.   Yu.  Zakharova   +32 more
doaj   +1 more source