Results 101 to 110 of about 6,761,337 (191)

Endothelial Cpt1a Inhibits Neonatal Hyperoxia‐Induced Pulmonary Vascular Remodeling by Repressing Endothelial‐Mesenchymal Transition

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Endothelial‐mesenchymal transition (EndoMT) causes pulmonary vascular remodeling in a murine model of bronchopulmonary dysplasia‐associated pulmonary hypertension. Endothelial reduction of carnitine palmitoyltransferase 1a (Cpt1a) is identified as a novel mechanism of lung EndoMT.
Xiaoyun Li, Katy Hegarty, Fanjie Lin, Jason L. Chang, Amro Abdalla, Karthik Dhanabalan, Sergey O. Solomevich, Wenliang Song, Karim Roder, Chenrui Yao, Wenju Lu, Peter Carmeliet, Gaurav Choudhary, Phyllis A. Dennery, Hongwei Yao   +14 more
wiley   +1 more source

Emergency Management of Intoxication‐Type Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.
ABSTRACT In many intoxication‐type inherited metabolic disorders, the accumulation of the toxic chemical can cause acute life‐threatening emergencies. Sometimes this is the inevitable consequence of a severe metabolic defect, but it is often triggered by catabolism.
J. Dexter Tarr, Andrew A. M. Morris
wiley   +1 more source

DATA-DRIVEN BIOMEDICINE INVESTIGATION OF GENETIC AND INFECTIOUS-BASED DISEASES USING OMICS DATA AND DATA SCIENCE METHODOLOGIES. [PDF]

, 2023
The binary model of existence consists of health and disease, with health being complete physical, mental, and social well-being and disease being a pathological process.
Agany, Diing
core   +1 more source

Renal Fanconi Syndrome and Hypophosphatemic Rickets in the Absence of Xenotropic and Polytropic Retroviral Receptor in the Nephron. [PDF]

, 2017
Tight control of extracellular and intracellular inorganic phosphate (Pi) levels is critical to most biochemical and physiologic processes. Urinary Pi is freely filtered at the kidney glomerulus and is reabsorbed in the renal tubule by the action of the ...
Baron, R., Gautschi, I., Haenzi, B., Hu, D.Z., Katanaev, V., Katanaeva, N., Koesters, R., Nikolaeva, S., Pradervand, S., Rotman, S., Schild, L.   +10 more
core   +1 more source

Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training [PDF]

, 2013
We sought to ascertain the time course of transcriptional events that occur in human skeletal muscle at the outset of resistance exercise (RE) training in RE naive individuals and determine whether the magnitude of response was associated with exercise ...
A. J. Murton, Benjamini Y, F. B. Stephens, F. Graber, K. Marimuthu, P. L. Greenhaff, R. Billeter, R. J. Hill, S. G. Des Etages   +8 more
core   +2 more sources

Association of HADHA expression with the risk of breast cancer: targeted subset analysis and meta-analysis of microarray data [PDF]

, 2012
Background The role of n-3 fatty acids in prevention of breast cancer is well recognized, but the underlying molecular mechanisms are still unclear. In view of the growing need for early detection of breast cancer, Graham et al.
Kulkarni, Hemant, Mamtani, Manju
core   +3 more sources

Whole exome sequencing reveals a dual diagnosis of BCAP31-related syndrome and glutaric aciduria III

Molecular Genetics and Metabolism Reports
Background: Biochemical testing is a common first-tier approach in the setting of genetic evaluation of patients with unexplained developmental delay. However, results can be unclear, and a plan for second-tier analysis must be determined based on the ...
Erin Huggins, David G. Jackson, Sarah P. Young, Priya S. Kishnani   +3 more
doaj   +1 more source

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening [PDF]

The first crystal structure is reported of a glutaryl-CoA dehydrogenase in the apo state without flavin adenine dinucleotide cofactor bound. Additional structures with small molecules complexed in the catalytic active site were obtained by fragment-based
Amanda L. Rychel, Aslanidis, Bart L. Staker, Begley, Berman, Berman, Chen, Chenna, Christensen, Darren W. Begley, Davies, Douglas R. Davies, Dwyer, Emsley, Fu, Garcia, Gomes, Goodman, Goodman, Hedlund, Keyser, Kim, Krissinel, Lance J. Stewart, Langer, Lenich, Mehlin, Morton, Murshudov, Otwinowski, Peter J. Myler, Rao, Robert C. Hartley, Stephen N. Hewitt, Strauss, Strauss, Studier, Swigonová, Thorpe, Tsai, Wesley C. Van Voorhis, Westover, Winn, Wischgoll, Wischgoll   +44 more
core   +2 more sources

Diversity and dispersal of a ubiquitous protein family: acyl-CoA dehydrogenases [PDF]

Acyl-CoA dehydrogenases (ACADs), which are key enzymes in fatty acid and amino acid catabolism, form a large, pan-taxonomic protein family with at least 13 distinct subfamilies.
B. Franz Lang, Battaile, Boden, Brown, Castresana, Claros, Cornell, Crooks, Edgar, Emanuelsson, Ensenauer, Finn, Fu, Gertraud Burger, Ghisla, Gray, Gray, Grecz, Gregersen, Hannenhalli, He, Hubbard, Ijlst, Ikeda, Iram, Izai, Kang, Keeling, Kikuchi, Kim, Kondrashov, Lang, Lu, Maggio-Hall, Mahadevan, Merritt, Mulder, Neuberger, Nurizzo, Ota, O’Brien, Palmer, Pauli, Pereto, Remm, Roe, Saenger, Shen, Shen, Small, Son, Stamatakis, Tiffany, Udvari, Wang, Weston, Yao-Qing Shen, Ye   +57 more
core   +2 more sources

A Comprehensive Study of the Avian Preen Wax’ Adaptive Role in Feather Microbial Ecology [PDF]

Organisms employ diverse adaptive strategies to ensure their protection against environmental microorganisms. Birds, in addition to other strategies common to vertebrates, stand out with two specific integumentary adaptations: feathers and the preen ...
Ançay, Laurie
core