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Brain JNK and metabolic disease [PDF]
Diabetologia, 2020 Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with central insulin and leptin resistance ...
Nogueiras, Rubén, Sabio, Guadalupe
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The landscape of metabolic brain alterations in Alzheimer’s disease [PDF]
Alzheimer's & Dementia, 2021 Abstract INTRODUCTION Alzheimer’s disease (AD) is accompanied by metabolic alterations both in the periphery and the central nervous system. However, so far, a global view of AD-associated metabolic changes in brain has been missing. METHODS
Richa Batra +12 more
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Brain Metabolic Alterations in Alzheimer’s Disease
International Journal of Molecular Sciences, 2022 The brain is one of the most energy-consuming organs in the body. Satisfying such energy demand requires compartmentalized, cell-specific metabolic processes, known to be complementary and intimately coupled. Thus, the brain relies on thoroughly orchestrated energy-obtaining agents, processes and molecular features, such as the neurovascular unit, the ...
Carlos G. Ardanaz +2 more
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Microbiome, 2021 Background Parkinson’s disease (PD) is a neurodegenerative disorder with no absolute cure. The evidence of the involvement of gut microbiota in PD pathogenesis suggests the need to identify certain molecule(s) derived from the gut microbiota, which has ...
Yan-fang Hou +18 more
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Frontiers in Physiology, 2023 Background: There is an inconsistent association between overweight/obesity and chronic obstructive pulmonary disease (COPD). Considering that different metabolic characteristics exist among individuals in the same body mass index (BMI) category, the ...
Yang Tian +53 more
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Cell Death Discovery, 2023 Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by the accumulation of amyloid β peptides (Aβ) and impaired glucose metabolism in the brain.
Chang Shan +11 more
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Brain cholesterol metabolism and Parkinson's disease [PDF]
Movement Disorders, 2019 ABSTRACTBackgroundCirculating cholesterol levels have been linked to PD, but not directly to brain physiology.ObjectiveTo assess whether brain cholesterol metabolism is related to PD.MethodsSixty PD patients and 64 controls were recruited from an academic movement disorder clinic (2009–2012).
Xuemei Huang +11 more
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Metabolic profiling of Alzheimer's disease brains [PDF]
Scientific Reports, 2013 AbstractAlzheimer's disease (AD) is an irreversible, progressive brain disease and can be definitively diagnosed after death through an examination of senile plaques and neurofibrillary tangles in several brain regions. It is to be expected that changes in the concentration and/or localization of low-molecular-weight molecules are linked to the ...
Inoue, Koichi +6 more
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iScience, 2023 Summary: The hypothalamus, as a vital brain region for endocrine and metabolism regulation, undergoes functional disruption during obesity.The anti-aging effect of metformin has come into focus.
Leilei Yang +7 more
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Frontiers in Cellular Neuroscience, 2017 Previously, we reported that fluoxetine acts on 5-HT2B receptor and induces epidermal growth factor receptor (EGFR) transactivation in astrocytes. Recently, we have found that chronic treatment with fluoxetine regulates Caveolin-1 (Cav-1)/PTEN/PI3K/AKT ...
Baoman Li +7 more
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