Results 21 to 30 of about 358,246 (264)

Brain Glucose Metabolism in Alzheimer’s Disease

The American Journal of the Medical Sciences, 1994
In vitro determination of brain glucose metabolism in the temporal cortex from patients with Alzheimer's disease showed a marked decrease when compared with nondemented, age-matched control subjects. Additional determinations on normal human temporal cortex obtained at autopsy demonstrated an age-dependent decline in the rate of glucose use. These data
R, Swerdlow, D L, Marcus, J, Landman, D, Kooby, W, Frey, M L, Freedman   +5 more
openaire   +2 more sources

Genome‐wide CRISPR/Cas9 screening for therapeutic targets in NSCLC carrying wild‐type TP53 and receptor tyrosine kinase genes

Clinical and Translational Medicine, 2022
Background Targeted drugs have greatly improved the therapeutic outcome of non‐small cell lung cancer (NSCLC) patients compared with conventional chemotherapy, whereas about one‐third of patients are so far not suitable for targeted therapy due to lack ...
Qianqian Wang, Jun Li, Jing Zhu, Jiaqi Mao, Chao Duan, Xiao Liang, Lingyun Zhu, Mengyan Zhu, Zhihong Zhang, Fan Lin, Renhua Guo   +10 more
doaj   +1 more source

Glutamine-Glutamate Cycle Flux Is Similar in Cultured Astrocytes and Brain and Both Glutamate Production and Oxidation Are Mainly Catalyzed by Aspartate Aminotransferase

Biology, 2017
The glutamine-glutamate cycle provides neurons with astrocyte-generated glutamate/γ-aminobutyric acid (GABA) and oxidizes glutamate in astrocytes, and it returns released transmitter glutamate/GABA to neurons after astrocytic uptake.
Leif Hertz, Douglas L Rothman
doaj   +1 more source

Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation

Frontiers in Physiology, 2020
It is well known that exposure to microgravity in astronauts leads to a plethora physiological responses such as headward fluid shift, body unloading, and cardiovascular deconditioning.
Marc Kermorgant, Nathalie Nasr, Nathalie Nasr, Marek Czosnyka, Marek Czosnyka, Dina N. Arvanitis, Ophélie Hélissen, Jean-Michel Senard, Jean-Michel Senard, Anne Pavy-Le Traon, Anne Pavy-Le Traon   +10 more
doaj   +1 more source

Metabolism-related brain morphology accelerates aging and predicts neurodegenerative diseases and stroke: a UK Biobank study

Translational Psychiatry, 2023
s Metabolic syndrome (MetS) is characterized by a constellation of metabolic risk factors, including obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) levels, hypertension, and hyperglycemia, and is associated with stroke and ...
Chenye Shen, Chaoqiang Liu, Anqi Qiu
doaj   +1 more source

Growth of Malignant Non-CNS Tumors Alters Brain Metabolome

Frontiers in Genetics, 2018
Cancer survivors experience numerous treatment side effects that negatively affect their quality of life. Cognitive side effects are especially insidious, as they affect memory, cognition, and learning.
Anna Kovalchuk, Anna Kovalchuk, Lilit Nersisyan, Rupasri Mandal, David Wishart, Maria Mancini, David Sidransky, David Sidransky, Bryan Kolb, Olga Kovalchuk   +9 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Classical homocystinuria: A common inborn error of metabolism? An epidemiological study based on genetic databases

Molecular Genetics & Genomic Medicine, 2020
Background Biallelic pathogenic variants in CBS gene cause the most common form of homocystinuria, the classical homocystinuria (HCU). The worldwide prevalence of HCU is estimated to be 0.82:100,000 [95% CI, 0.39–1.73:100,000] according to clinical ...
Giovana R. Weber Hoss, Fernanda Sperb‐Ludwig, Ida V. D. Schwartz, Henk J. Blom   +3 more
doaj   +1 more source

Astrocytic glycogen metabolism in the healthy and diseased brain [PDF]

Journal of Biological Chemistry, 2018
The brain contains a fairly low amount of glycogen, mostly located in astrocytes, a fact that has prompted the suggestion that glycogen does not have a significant physiological role in the brain. However, glycogen metabolism in astrocytes is essential for several key physiological processes and is adversely affected in disease.
Bak, Lasse K, Walls, Anne B, Schousboe, Arne, Waagepetersen, Helle S   +3 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source