Results 31 to 40 of about 358,246 (264)
Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
Membranes, 2021 Wnt signaling pathways constitute a group of signal transduction pathways that direct many physiological processes, such as development, growth, and differentiation.
Mustafa Karabicici +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Brain fuel metabolism, aging, and Alzheimer’s disease [PDF]
Nutrition, 2011 Lower brain glucose metabolism is present before the onset of clinically measurable cognitive decline in two groups of people at risk of Alzheimer's disease--carriers of apolipoprotein E4, and in those with a maternal family history of AD. Supported by emerging evidence from in vitro and animal studies, these reports suggest that brain hypometabolism ...
Cunnane, Stephen +16 more
openaire +3 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The Journal of Nutrition, Health and AgingObjective: Serum 25-hydroxyvitamin D [25(OH)D] is known to be associated with depression. However, the evidence concerning the association between vitamin D status and depressive episodes in population with prediabetes and diabetes remains limited.
Huaxue Li +11 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Orphanet Journal of Rare DiseasesStudies in adults with PKU have mainly focused on the neuropsychiatric complications that may arise in individuals who are unable to maintain the recommended lifetime diet. Some recent epidemiological studies suggest to consider other complications.
Yann Dos Santos +7 more
doaj +1 more source
Ceramide signalling in inherited and multifactorial brain metabolic diseases
Neurobiology of Disease, 2020 In recent years, research on sphingolipids, particularly ceramides, has attracted increased attention, revealing the important roles and many functions of these molecules in several human neurological disorders.
Devesh C. Pant +2 more
doaj +1 more source
Scientific Reports, 2022 Despite national and international efforts for the prevention of metabolic syndrome and its underlying diseases/disorders, its prevalence is still rising, especially in the middle-aged population.
Farida El Gaamouch +13 more
doaj +1 more source
NANS-CDG: Delineation of the Genetic, Biochemical, and Clinical Spectrum
Frontiers in Neurology, 2021 Background: NANS-CDG is a recently described congenital disorder of glycosylation caused by biallelic genetic variants in NANS, encoding an essential enzyme in de novo sialic acid synthesis.
Bibiche den Hollander +42 more
doaj +1 more source