Results 11 to 20 of about 358,246 (264)
iScience, 2023 Summary: Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism is still unclear. Here, we established a mouse model carrying the dominant-negative HNF1α P291fsinsC mutation (hHNF1Amut/-) and found that the mutant mice ...
Moke Liu +11 more
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Brain hypometabolism in rare genetic neurodegenerative disease: Niemann-Pick disease type C, spinocerebellar ataxia and Huntington disease assessed by FDG PET [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2021 Brain metabolic imaging using 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) with contemporaneous low-dose CT may be used to assess neurodegenerative diseases.
Yung Hsiang Kao +4 more
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Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion
ASN Neuro, 2015 The epidermal growth factor receptor (EGFR) is linked to the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and Raf/mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK 1/2 ) signaling pathways.
Jing Zhou +5 more
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Frontiers in Integrative Neuroscience, 2017 The 1988 observation by Fox et al. (1988) that brief intense brain activation increases glycolysis (pyruvate formation from glucose) much more than oxidative metabolism has been abundantly confirmed.
Leif Hertz, Ye Chen
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ASN Neuro, 2014 This study investigates the role of the intracellular adenosine transporter equilibrative nucleoside transporter 3 (ENT3) in stimulated release of the gliotransmitter adenosine triphosphate (ATP) from astrocytes.
Dan Song +5 more
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Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders
Molecular Brain, 2019 It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose ...
Chang Shan +6 more
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Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease [PDF]
Frontiers in Neuroscience, 2021 Alzheimer’s disease (AD) is the most common form of age-related dementia. Despite decades of research, the etiology and pathogenesis of AD are not well understood. Brain glucose hypometabolism has long been recognized as a prominent anomaly that occurs in the preclinical stage of AD.
Xin Zhang +3 more
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Frontiers in Molecular Neuroscience, 2018 Osteoblasts derived osteocalcin (OCN) is recently reported to be involved in dopaminergic neuronal development. As dopaminergic neuronal injury in the substantia nigra (SN) is a pathological hallmark of Parkinson’s disease (PD), we investigated whether ...
Xing-zhi Guo +9 more
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Implications of glial metabolic dysregulation in the pathophysiology of neurodegenerative diseases
Neurobiology of Disease, 2022 Glial cells are the most abundant cells of the brain, outnumbering neurons. These multifunctional cells are crucial for maintaining brain homeostasis by providing trophic and nutritional support to neurons, sculpting synapses, and providing an immune ...
Ruqayya Afridi +2 more
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Sphingolipid metabolism in brain insulin resistance and neurological diseases
Frontiers in Endocrinology, 2023 Sphingolipids, as members of the large lipid family, are important components of plasma membrane. Sphingolipids participate in biological signal transduction to regulate various important physiological processes such as cell growth, apoptosis, senescence,
Meng Mei +4 more
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