Results 111 to 120 of about 80,770 (310)

Effect of Intramuscular Adrenaline on Histamine‐Induced Hypotension: A Randomised Placebo‐Controlled Pilot Trial

open access: yesAllergy, EarlyView.
Histamine infusions induce reproducible severe hypotension. Intramuscular adrenaline showed ‘supposedly therapeutic’ plasma concentrations but did not produce a sustained clinically relevant improvement in shock in the majority of recipients. These findings question adrenaline pharmacokinetic surrogate thresholds and support the need for faster and ...
Matthias Weiss‐Tessbach   +12 more
wiley   +1 more source

Bioequivalence study of two formulations of lurasidone film coated tablets in healthy subjects under fed conditions

open access: yesScientific Reports
To define the bioequivalence (BE) of two orally administered film coated tablets containing 40 mg lurasidone hydrochloride. A single-dose, open-label, randomized two-way crossover trial was conducted under fed conditions, with a washout period of at ...
Gökçe Sözer   +6 more
doaj   +1 more source

Distributive inverse semigroups and non-commutative Stone dualities [PDF]

open access: yes, 2013
We develop the theory of distributive inverse semigroups as the analogue of distributive lattices without top element and prove that they are in a duality with those etale groupoids having a spectral space of identities, where our spectral spaces are not
Lawson, Mark V, Lenz, Daniel H
core  

Anterior chamber flare and central macular thickness after trabeculectomy versus after phacoemulsification

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To compare the inflammatory response in the eye after trabeculectomy to after phacoemulsification, focusing on anterior chamber flare (AC flare) and central macular thickness (CMT). Methods Data from 436 participants in two randomized controlled trials were analysed.
Yasmeen Ahmed   +5 more
wiley   +1 more source

Prevalence of bedaquiline resistance in patients with drug-resistant tuberculosis: a systematic review and meta-analysis

open access: yesBMC Infectious Diseases
Background Drug-resistant tuberculosis (TB) remains a major global public health challenge. While bedaquiline (BDQ) offers improved treatment outcomes for patients with multi-drug resistant TB (MDR-TB), its widespread use has led to the emergence of BDQ ...
Xinyang Hu   +4 more
doaj   +1 more source

Grain Boundary Precipitation Control of GCP Phase Using TCP or A2 Phase in Ni-Based Alloys [PDF]

open access: gold, 2022
Shuntaro Ida   +4 more
openalex   +1 more source

Randomized, single‐centre, double‐blinded repeated dose investigation of safety and tolerability of ocular administrations of a novel silica eye drop product in healthy volunteers

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Managing ocular diseases often requires frequent eye drop administration, which can challenge patient compliance. A long‐acting eye drop technology using an amorphous synthetic silica composite was developed to address this. Our study aimed to assess the safety and tolerability of the Silica Eye Drop platform in healthy volunteers over
Aleksandra Poluianova   +5 more
wiley   +1 more source

Generalized Cardinal Polishing Splines Signal Reconstruction

open access: yesMathematics
Sampling and reconstruction are indispensable processes in signal processing, and appropriate foundations are crucial for spline reconstruction models.
Fangli Sun, Zhanchuan Cai
doaj   +1 more source

Mesopic microperimetry in Stargardt disease: Application and reliability

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Mesopic microperimetry (mMP) is a promising functional endpoint in clinical trials for Stargardt disease type 1 (STGD1). This study evaluated the test–retest variability of mMP and influencing factors, which is essential for ensuring reliability in future STGD1 trials.
Sybren H. Kootstra   +12 more
wiley   +1 more source

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