Results 191 to 200 of about 29,893 (266)

PK and PK/PD Modeling of Bcl2 Inhibitor S65487 in Patients With AML and Investigation of Nonlinearity With Microdosing

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT This work aims to assess the S65487‐induced disruption of the B‐cell lymphoma‐2 (Bcl2)/Bcl2‐like protein 11 (Bim) complex at therapeutic doses via a pharmacokinetic/pharmacodynamic model and to reconcile pharmacokinetic data from microdoses and therapeutic doses in a single population pharmacokinetic model. The first model consists of a linear
Chloé Burlot, François Riglet, Mathilde Romagnoli, Ariane Leconte, Audrey Delmas, Antonin Schmitt, Sylvain Fouliard   +6 more
wiley   +1 more source

Vulcano island: the new high resolution digital surface model post 2021-2022 volcanic unrest. [PDF]

Sci Data
Bisson M, Gianardi R, Iacono F, Madonia P, De Astis G, Spinetti C.   +5 more
europepmc   +1 more source

Surface complexity and gastropod exclusion drive colonization of an intertidal eco‐engineered structure

Journal of Applied Ecology, Volume 63, Issue 7, July 2026.
Habitat complexity and grazing by invertebrate molluscs shaped community structure and ecosystem functioning on eco‐engineered substrates through distinct mechanisms. Increasing structural complexity increased invertebrate species richness with limited effects on macroalgae and carbon flux, while grazer exclusion had strong effects on macroalgal ...
Corryn L. Knapp, Andrew L. Chang
wiley   +1 more source

Effect of Ultrasound‐Guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures: A Randomized Controlled Noninferiority Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Closed reduction of distal radius fractures is painful, and current analgesic strategies may be inadequate. Ultrasound‐guided lateral infraclavicular brachial plexus block may offer complete analgesia and muscle relaxation, potentially improving patient comfort and reduction quality.
Mathias Therkel Steensbæk, Sina Yousef, Aurelien‐Xuan Rosendal Bahuet, Rasmus Linnebjerg Knudsen, Rikke Helene Frølund Bjulf, Sanja Pisljagic, Jens Haavig Thomsen, Zofia Piosik, Peter Bak Kaaber, Christian Rothe, Cecilie Dupont Harwood, Anne‐Sofie Linde Jellestad, Kai Henrik Wiborg Lange, Lars Hyldborg Lundstrøm, Anders Kehlet Nørskov   +14 more
wiley   +1 more source

The Impacts of Essential Gcp/TsaD Protein on Cell Morphology, Virulence Expression, and Antibiotic Susceptibility in <i>Staphylococcus aureus</i>. [PDF]

Microorganisms
Guo H, Lei T, Yang J, Han L, Wang Y, Ji Y.   +5 more
europepmc   +1 more source

Metacognition and cognitive dysfunction in post-COVID condition. [PDF]

Front Psychol
Oliver-Mas S, Delgado-Alonso C, Díez-Cirarda M, Catricalà E, Cuevas C, Valles-Salgado M, Barroso Y, López-Carbonero JI, Alcalá Ramírez Del Puerto JM, Cappa SF, Matias-Guiu JA.   +10 more
europepmc   +1 more source

Legal Basis and Regulatory Requirements for Utilizing Real-World Evidence in Medical Product Regulatory Decision-Making. [PDF]

Pharmacoepidemiol Drug Saf
Park S, Han E.
europepmc   +1 more source