Results 21 to 30 of about 80,770 (310)

Disease modification and symptom relief in osteoarthritis using a mutated GCP‐2/CXCL6 chemokine

EMBO Molecular Medicine, 2022
We showed that the chemokine receptor C‐X‐C Motif Chemokine Receptor 2 (CXCR2) is essential for cartilage homeostasis. Here, we reveal that the CXCR2 ligand granulocyte chemotactic protein 2 (GCP‐2) was expressed, during embryonic development, within the
Sara Caxaria, Nikolaos Kouvatsos, Suzanne E Eldridge, Mario Alvarez‐Fallas, Anne‐Sophie Thorup, Daniela Cici, Aida Barawi, Ammaarah Arshed, Danielle Strachan, Giulia Carletti, Xinying Huang, Sabah Bharde, Melody Deniz, Jacob Wilson, Bethan L Thomas, Costantino Pitzalis, Francesco Paolo Cantatore, Manasi Sayilekshmy, Shafaq Sikandar, Frank P Luyten, Thomas Pap, Joanna C Sherwood, Anthony J Day, Francesco Dell'Accio   +23 more
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CP violation and modular symmetries [PDF]

, 2001
We reconsider the origin of CP violation in fundamental theory. Existing string models of spontaneous CP violation make ambiguous predictions, due to the arbitrariness of CP transformation and the apparent non-invariance of the results under duality.
A. G. Cohen, A. Strominger, D. Bailin, D. Bailin, D. Bailin, D. Bailin, D. Bailin, F. J. Botella, G. C. Branco, G. Eyal, H. P. Nilles, J. Bernabéu, J. Giedt, J. Lauer, J.-P. Derendinger, J.-P. Derendinger, K. Choi, K. Choi, L. E. Ibáñez, L. E. Ibáñez, L. E. Ibáñez, L. M. Krauss, M. Brhlik, M. Brhlik, M. Brhlik, M. Cvetič, M. Dine, M. Dine, M. Kobayashi, P. Hořava, R. Dijkgraaf, S. A. Abel, S. A. Abel, S. Ferrara, S. Weinberg, T. D. Lee, T. D. Lee, T. Ibrahim, T. Kobayashi, Thomas Dent, V. A. Rubakov, Y. Kizukuri, Z. Lalak   +42 more
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Drug Import Replacement Is a Perspective Direction of the Development of Russian Economy

Управленческое консультирование, 2018
The development of the domestic pharmaceutical industry as a science-intensive and hightech sector of the country’s economy is, among other things, a pledge of the drug safety of the state, especially in the conditions of a modern complex political ...
K. D. Grigorieva
doaj   +1 more source

A dose-escalation study of HP501, a highly selective URAT1 inhibitor, in male Chinese patients with hyperuricemia

Scientific Reports, 2023
HP501 is a highly selective renal urate transporter 1 (URAT1) inhibitor used for treating hyperuricemia. This study aimed to evaluate the tolerability, pharmacokinetics, and pharmacodynamics of HP501 in male Chinese patients.
Ruilin Ding, Xuehong Deng, Longxia Chen, Yang Zhen, Xinghai Li, Tengqiong Xiong, Yuanhua Zhang, Hong Chen, Xiaojing Hu, Yun Li, Yi Zhou, Feng Jiang, Qing Peng, Xiaojie Wang   +13 more
doaj   +1 more source

South Pole Telescope Software Systems: Control, Monitoring, and Data Acquisition [PDF]

, 2012
We present the software system used to control and operate the South Pole Telescope. The South Pole Telescope is a 10-meter millimeter-wavelength telescope designed to measure anisotropies in the cosmic microwave background (CMB) at arcminute angular ...
Ade, P., Aird, K. A., Austermann, J. E., Beall, J. A., Becker, D., Bender, A. N., Benson, B. A., Bleem, L. E., Britton, J., Carlstrom, J. E., Chang, C. L., Chiang, H. C., Cho, H-M., Crawford, T. M., Crites, A. T., Datesman, A., de Haan, T., Dobbs, M. A., Everett, W., Ewall-Wice, A., George, E. M., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holzapfel, W. L., Hoover, S., Huang, N., Hubmayr, J., Irwin, K. D., Karfunkle, M., Keisler, R., Kennedy, J., Lee, A. T., Leitch, E., Li, D., Lueker, M., Marrone, D. P., McMahon, J. J., Mehl, J., Meyer, S. S., Montgomery, J., Montroy, T. E., Nagy, J., Natoli, T., Nibarger, J. P., Niemack, M. D., Novosad, V., Padin, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Smecher, G., Stalder, B., Story, K., Tucker, C., Vanderlinde, K., Vieira, J. D., Wang, G., Williamson, R., Yefremenko, V., Yoon, K. W., Young, E.   +66 more
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Assessing clinical research coordinator knowledge of good clinical practice: An evaluation of the state of the art and a test validation study

Journal of Clinical and Translational Science, 2020
This paper describes the development and validation of a new 32-item test of knowledge of good clinical practice (GCP) administered to 625 clinical research coordinators.
James M. DuBois, Jessica T. Mozersky, Alison L. Antes, Kari Baldwin, Michelle Jenkerson   +4 more
doaj   +1 more source

Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]

, 2003
Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P., Holz, Richard C., Swierczek, Sabina I.   +2 more
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Transition from connected to fragmented vegetation across an environmental gradient: scaling laws in ecotone geometry [PDF]

, 2009
A change in the environmental conditions across space—for example, altitude or latitude—can cause significant changes in the density of a vegetation type and, consequently, in spatial connectivity.
Gastner, Michael T., Oborny, Beata, Pruessner, Gunnar, Zimmermann, D. K.   +3 more
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The essentiality of staphylococcal Gcp is independent of its repression of branched-chain amino acids biosynthesis. [PDF]

PLoS ONE, 2012
Our previous studies revealed that the staphylococcal protein Gcp is essential for bacterial growth; however, the essential function of Gcp remains undefined.
Ting Lei, Junshu Yang, Li Zheng, Todd Markowski, Bruce A Witthuhn, Yinduo Ji   +5 more
doaj   +1 more source

FDE-vdW: A van der Waals Inclusive Subsystem Density-Functional Theory [PDF]

, 2014
We present a formally exact van der Waals inclusive electronic structure theory, called FDE-vdW, based on the Frozen Density Embedding formulation of subsystem Density-Functional Theory.
Eshuis, Henk, Kevorkyants, Ruslan, Pavanello, Michele   +2 more
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