Results 11 to 20 of about 29,972 (265)

Practical technical solution for clay-contaminated sands used in concrete

open access: yesMATEC Web of Conferences, 2017
Sand, whether natural or manufactured, shows in many instances varying degrees of high levels of clay contamination. This fact is encountered in different parts of the globe and can lead to serious problems in adjusting concrete mix proportions and ...
Estephane Pierre, Rieder Klaus-Alexander
doaj   +1 more source

The need for ‘Good Clinical Practice’ in health care research

open access: yesSouth African Family Practice, 2009
Randomised controlled trials form the foundation for ‘evidence-based-medicine’, but the results of such research can be relied upon only if it was conducted according to principles and standards collectively referred to as ‘Good Clinical Practice’ (GCP).
M.H.R. NoorZurani   +6 more
doaj   +1 more source

UV resonance Raman spectroscopy of the supramolecular ligand guanidiniocarbonyl indole (GCI) with 244 nm laser excitation

open access: yesBeilstein Journal of Organic Chemistry, 2020
Ultraviolet resonance Raman (UVRR) spectroscopy is a powerful vibrational spectroscopic technique for the label-free monitoring of molecular recognition of peptides or proteins with supramolecular ligands such as guanidiniocarbonyl pyrroles (GCPs).
Tim Holtum   +4 more
doaj   +1 more source

Disease modification and symptom relief in osteoarthritis using a mutated GCP‐2/CXCL6 chemokine

open access: yesEMBO Molecular Medicine, 2022
We showed that the chemokine receptor C‐X‐C Motif Chemokine Receptor 2 (CXCR2) is essential for cartilage homeostasis. Here, we reveal that the CXCR2 ligand granulocyte chemotactic protein 2 (GCP‐2) was expressed, during embryonic development, within the
Sara Caxaria   +23 more
doaj   +1 more source

A dose-escalation study of HP501, a highly selective URAT1 inhibitor, in male Chinese patients with hyperuricemia

open access: yesScientific Reports, 2023
HP501 is a highly selective renal urate transporter 1 (URAT1) inhibitor used for treating hyperuricemia. This study aimed to evaluate the tolerability, pharmacokinetics, and pharmacodynamics of HP501 in male Chinese patients.
Ruilin Ding   +13 more
doaj   +1 more source

The C-terminal domain of the novel essential protein Gcp is critical for interaction with another essential protein YeaZ of Staphylococcus aureus. [PDF]

open access: yesPLoS ONE, 2011
Previous studies have demonstrated that the novel protein Gcp is essential for the viability of various bacterial species including Staphylococcus aureus; however, the reason why it is required for bacterial growth remains unclear.
Ting Lei   +6 more
doaj   +1 more source

Assessing clinical research coordinator knowledge of good clinical practice: An evaluation of the state of the art and a test validation study

open access: yesJournal of Clinical and Translational Science, 2020
This paper describes the development and validation of a new 32-item test of knowledge of good clinical practice (GCP) administered to 625 clinical research coordinators.
James M. DuBois   +4 more
doaj   +1 more source

Drug Import Replacement Is a Perspective Direction of the Development of Russian Economy

open access: yesУправленческое консультирование, 2018
The development of the domestic pharmaceutical industry as a science-intensive and hightech sector of the country’s economy is, among other things, a pledge of the drug safety of the state, especially in the conditions of a modern complex political ...
K. D. Grigorieva
doaj   +1 more source

The essentiality of staphylococcal Gcp is independent of its repression of branched-chain amino acids biosynthesis. [PDF]

open access: yesPLoS ONE, 2012
Our previous studies revealed that the staphylococcal protein Gcp is essential for bacterial growth; however, the essential function of Gcp remains undefined.
Ting Lei   +5 more
doaj   +1 more source

Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells

open access: yesFrontiers in Pharmacology, 2021
Glucocappasalin (GCP), a natural product derived from the seeds of Descurainia sophia (L.) Webb. ex Prantl, exhibits potential antitumor activity in HeLa cervical carcinoma cells.
Guangya Xu   +9 more
doaj   +1 more source

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