Results 21 to 30 of about 40,166 (303)

Assessing clinical research coordinator knowledge of good clinical practice: An evaluation of the state of the art and a test validation study

Journal of Clinical and Translational Science, 2020
This paper describes the development and validation of a new 32-item test of knowledge of good clinical practice (GCP) administered to 625 clinical research coordinators.
James M. DuBois, Jessica T. Mozersky, Alison L. Antes, Kari Baldwin, Michelle Jenkerson   +4 more
doaj   +1 more source

A dose-escalation study of HP501, a highly selective URAT1 inhibitor, in male Chinese patients with hyperuricemia

Scientific Reports, 2023
HP501 is a highly selective renal urate transporter 1 (URAT1) inhibitor used for treating hyperuricemia. This study aimed to evaluate the tolerability, pharmacokinetics, and pharmacodynamics of HP501 in male Chinese patients.
Ruilin Ding, Xuehong Deng, Longxia Chen, Yang Zhen, Xinghai Li, Tengqiong Xiong, Yuanhua Zhang, Hong Chen, Xiaojing Hu, Yun Li, Yi Zhou, Feng Jiang, Qing Peng, Xiaojie Wang   +13 more
doaj   +1 more source

Maps of GCP-PC prediction.

, 2020
GCP-PC prediction (log10 of k USD/person) for the global case using the top predictors (see Table 4). Top left: top predictor. Top right: top two predictors. Bottom left: top three predictors. Bottom right: top six predictors. Compare with the actual GCP-
Alberto Troccoli (8520099)
core   +1 more source

Drug Import Replacement Is a Perspective Direction of the Development of Russian Economy

Управленческое консультирование, 2018
The development of the domestic pharmaceutical industry as a science-intensive and hightech sector of the country’s economy is, among other things, a pledge of the drug safety of the state, especially in the conditions of a modern complex political ...
K. D. Grigorieva
doaj   +1 more source

The essentiality of staphylococcal Gcp is independent of its repression of branched-chain amino acids biosynthesis. [PDF]

PLoS ONE, 2012
Our previous studies revealed that the staphylococcal protein Gcp is essential for bacterial growth; however, the essential function of Gcp remains undefined.
Ting Lei, Junshu Yang, Li Zheng, Todd Markowski, Bruce A Witthuhn, Yinduo Ji   +5 more
doaj   +1 more source

GCP

, 2018
GCP is a two-million-word corpus of Persian containing a large body of naturally-occurring utterances and written texts. GCP represents a wide variety of Persian speakers and documents diverse language situations and uses.
Ariana Mohammadi (6032699)
core   +1 more source

Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells

Frontiers in Pharmacology, 2021
Glucocappasalin (GCP), a natural product derived from the seeds of Descurainia sophia (L.) Webb. ex Prantl, exhibits potential antitumor activity in HeLa cervical carcinoma cells.
Guangya Xu, Xueling Yan, Zhongjia Hu, Lulu Zheng, Ke Ding, Yamei Zhang, Yi Qing, Tao Liu, Lijia Cheng, Zheng Shi   +9 more
doaj   +1 more source

The determination of Gcp binding to YeaZ.

, 2013
(A) Yeast two hybrid analysis of interaction between Gcp and YeaZ on histidine, leucine, and tryptophan drop out synthetic complete (SC-His, -Leu, -Trp) plates with 3-amino-1,2,4,-triazole (3-AT) and SC plates lacking adenine, leucine, and tryptophan (SC-
Yinduo Ji (114234), Xudong Liang (225069), Bruce Walcheck (351317), Junshu Yang (114232), Meiying Yan (114226), Li Zheng (15952), Ting Lei (304331)   +6 more
core   +1 more source

Evaluation of Ornidazole Tablets Bioequivalence in Chinese Healthy Participants Under Fasted and Fed Conditions Using Pharmacokinetic Parameters

Drugs in R&D
Background and Objective Ornidazole, the third generation of nitroimidazole derivatives after metronidazole and tinidazole, it exerts both bactericidal and antiprotozoal effects.
Yanrong Wang, Yuanyuan He, Weihong Li, Hongmin LI, Liyuan Tang, Xinya Dai, Yingzi Pei, Lijing Gao   +7 more
doaj   +1 more source

Gene transcription change due to the depletion of Gcp.

, 2013
aThe fold change represents the transcription levels of genes with the depletion of Gcp compared with those during the induction of gcp transcription with IPTG (200 μM) at exponential phase of growth (OD600 nm ∼0.5).
Yinduo Ji (114234), Bruce A. Witthuhn (304335), Todd Markowski (304333), Junshu Yang (114232), Li Zheng (15952), Ting Lei (304331)   +5 more
core   +1 more source