Results 51 to 60 of about 7,546 (298)

Investigating Pompeii Subsoil Using Geomatics and Geophysics Merged Analyses

Archaeological Prospection, EarlyView.
ABSTRACT The archaeological site of Pompeii represents an exceptional context for the application of non‐invasive and integrated investigation methods aimed at enhancing the understanding of both exposed and buried remains. This study presents the results of multidisciplinary research conducted in the Palestra Grande site, a large and strategically ...
Valentina Santoro, Antonio Merico, Vincenzo Sapia, Gianluca Catanzariti, Valerio Materni, Giacomo Patrucco, Riccardo Olivito, Anna Anguissola, Ilaria Cangiano, Antonia Spanò   +9 more
wiley   +1 more source

Implementing GCPs in Asia [PDF]

The Quality Assurance Journal, 2000
The implementation of International Conference on Harmonization (ICH)-Good Clinical Practice (GCP) standards in China, Taiwan, Thailand and Japan poses some unique challenges due to cultural influences, particularly in Japan. Auditing experiences were generally positive in all countries with auditing by a Western company being viewed as a positive and ...
openaire   +1 more source

A university‐certified course on dossier assessment for regulatory scientists in Africa—Reporting on our 5‐year experience

British Journal of Clinical Pharmacology, EarlyView.
Aim The shortage of trained clinical assessors in African National Regulatory Authorities (NRAs) poses a challenge to effective regulatory decision‐making. Developed in line with the World Health Organization's (WHO) Global Competency Framework (WHO‐GCF), a university‐certified short course, Dossier assessment for clinical assessors in Africa, was ...
Stephanie Leigh, Boitumelo Semete‐Makokotlela, Ivana Škrnjug‐Yudov, David Mukanga, Delese Mimi Darko, Eric Karikari‐Boateng, Peter Stonier, Luther Gwaza, Precious Matsoso, Bernd Rosenkranz, Birka Lehmann, Arnold G. Vulto, John G. Woodland, Shabir Banoo, Frieda Shigwedha, Maphutheho Selikane, Unathi Mabona‐Mgoqi, Asare Yeboah, Ntombi Mthembu, Goonaseelan ( Colin) Pillai   +19 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

A Station Level Early Warning Method of Cascading Failures Across Space Based on Attack Gain and Cost Principle in GCPS

, 2020
In order to accurately detect the cascading failures across space (CFAS) caused by cyber attacks in grid cyber-physical systems (GCPS), a station-level early warning method for CFAS is proposed based on attack gain and cost principle (AGCP). Firstly, the
Jian QIU, Yufei WANG, June LI
core   +1 more source

Absorption, distribution, metabolism and excretion of londamocitinib after single‐dose inhaled, intravenous and oral administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open‐label, two‐part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (ADME) of inhaled londamocitinib ...
Camille Riff, Peter Bold, Maria Heijer, Ryan A. Bragg, Danielle Steele, Tina Jellesmark Jensen, Davinder P. S. Dosanjh, Sabrina I. Hanswijk‐Bartelds, Esther van Duijn, Elwin R. Verheij, Somasekhara Menakuru, Rod Hughes, Helena Dahlbäck   +12 more
wiley   +1 more source

Phase 1, open‐label, randomized study of the elecoglipron pharmacokinetic profile in healthy participants under fed and fasted conditions

British Journal of Clinical Pharmacology, EarlyView.
Aims Elecoglipron (AZD5004/ECC5004) is an oral small‐molecule glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) in development for weight management in people living with obesity or overweight and type 2 diabetes. This study aimed to characterize the pharmacokinetics (PK) profiles of two formulations of elecoglipron under fed and fasted conditions ...
Jianfeng Xu, Amina Haggag, Laurie Butcher, Haihui Liu, Wen Chen, Xuefeng Sun, Aruni Jha, Hongtao Yu, Anis Khan, Victoria E. R. Parker, Christer Tannergren, Xiaoliang Pan, Jianfeng Xu, Jingye Zhou   +13 more
wiley   +1 more source

Nanogel, a versatile nanoscopic platform for the simultaneous delivery of acyclovir and lignocaine for the treatment of Herpes simplex virus infection: formulation and characterizations

Nano Express
This study was designed to develop a nanogel formulation incorporating acyclovir and lignocaine (ALN). Various formulations were developed in which ALN-V (formulation-V) was optimized.
Adnan Aslam, Barkat A Khan, M Khalid Khan, Muhammad Bilal K Niazi   +3 more
doaj   +1 more source

Evaluation of four gridded climate products for streamflow and drought simulations in the Kelantan River Basin, Malaysia

Geocarto International
Gridded climate products (GCPs) play a vital role in hydro-climatic modeling by overcoming the limitations of gauge data. This study compares the performance of the recently launched NASA POWER and ERA5-Land, with CHIRPS and APHRODITE, in simulating ...
Hongrong Du, Mou Leong Tan, Kwok Pan Chun, Fei Zhang   +3 more
doaj   +1 more source

Preparation and applications of guard cell protoplasts from the leaf epidermis of Solanum lycopersicum

Plant Methods, 2018
Background Guard cell protoplasts (GCPs) isolated from various plants have proven to be especially useful for studies of signal transduction pathways and plant development.
Xuehui Yao, Wenchao Zhao, Rui Yang, Jianli Wang, Fukuan Zhao, Shaohui Wang   +5 more
doaj   +1 more source