Results 61 to 70 of about 7,546 (298)

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

MULTI-SCALE MATCHING FOR THE AUTOMATIC LOCATION OF CONTROL POINTS IN LARGE SCALE AERIAL IMAGES USING TERRESTRIAL SCENES [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2014
A technique to automatically locate Ground Control Points (GCPs) in large aerial images is presented considering the availability of low accuracy direct georeferencing data. The approach is based on image chips of GCPs extracted from vertical terrestrial
A. Berveglieri, A. M. G. Tommaselli
doaj   +1 more source

Adapting the WHO Global Competency Framework for Regulators of Medicines: Implementation lessons from the South African Health Products Regulatory Authority

British Journal of Clinical Pharmacology, EarlyView.
Aims Medicines regulatory authorities require skilled staff to ensure timely, consistent and high‐quality regulatory decision making. The World Health Organization Global Competency Framework (WHO‐GCF) for Regulators of Medicines provides a common reference for defining regulatory workforce competencies while allowing adaptation to local needs.
Goonaseelan Pillai, Boitumelo Semete‐Makokotlela, Innocent G. Asiimwe, Suraiya Suliman, Shyamli Munbodh, David Mukanga, Douglas McNair, Sakhile Dube‐Mwedzi, Bernd Rosenkranz, Luther Gwaza   +9 more
wiley   +1 more source

Deletion of Gli3 in mice causes abnormal frontal bone morphology and premature synostosis of the interfrontal suture

Frontiers in Physiology, 2012
Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder with polydactyly and syndactyly of the limbs and a broad spectrum of craniofacial abnormalities.
Lotta eVeistinen, Maarit eTakatalo, Dörthe A. Kesper, Andrea eVortkamp, David P Rice, David P Rice   +5 more
doaj   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Analysis of UAS Flight Altitude and Ground Control Point Parameters on DEM Accuracy along a Complex, Developed Coastline

Remote Sensing, 2020
Measuring beach topography accurately and with high spatial resolution is an important aspect of coastal management and is crucial for understanding changes in beach morphology, especially along complex, three-dimensional shorelines.
Taylor Zimmerman, Karine Jansen, Jon Miller   +2 more
doaj   +1 more source

Sustainable Corporate Loans: A Systematic Literature Review and Future Research Agenda

Business Strategy and the Environment, EarlyView.
ABSTRACT This paper presents a systematic literature review of sustainable corporate loans (SCLs), including green loans and sustainability‐linked loans, to synthesise current academic knowledge and outline future research directions. Using a PRISMA protocol and a bibliometric analysis of 102 peer‐reviewed articles published in AJG‐ranked journals (3 ...
Md Nurul Islam Sohel, Abdullah Iqbal, Rizwan Ahmed, Vasileios Pappas   +3 more
wiley   +1 more source

Accuracy Analysis of a Dam Model from Drone Surveys

Sensors, 2017
This paper investigates the accuracy of models obtained by drone surveys. To this end, this work analyzes how the placement of ground control points (GCPs) used to georeference the dense point cloud of a dam affects the resulting three-dimensional (3D ...
Elena Ridolfi, Giulia Buffi, Sara Venturi, Piergiorgio Manciola   +3 more
doaj   +1 more source

mGFP-labeled, postmitotic migrating GCPs in the EGL with trailing and leading processes at P8.

, 2014
Left: P3-injected P8 cerebellum, mGFP  =  cells after recombination, mTomato  =  cells without recombination. Frames A-C are shown enlarged, A′-C′  =  further enlargement to show mGFP-immunoreactive GCPs in the inner EGL, A″-C″  =  mTomato. Arrowheads in
Thomas Günther (247952), Joachim Herz (28421), Petra May (581258), Roland Schüle (169570), Laura Steller (581257), Theresa Pohlkamp (581256), Michael Frotscher (226745), Hans H. Bock (447018)   +7 more
core   +1 more source

Quantification of Palmar and Digital Epidermal Thickness and Sweat Duct Density

Clinical Anatomy, EarlyView.
ABSTRACT Palmar digital skin, with its high density of epidermal sweat glands and unique stratum corneum, derives its autonomic innervation from peripheral nerves. Understanding the changes to these structures could serve as objective proxy markers following peripheral nerve injury and interventions to promote regeneration.
Elizabeth Jones, Hanaa N. Mughal, Roxana Moscalu, Malachy Columb, Christopher Duff, Mark Dickinson, Adam J. Reid, Ralph N. A. Murphy   +7 more
wiley   +1 more source